N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2
Cetrorelix
CAS: 120287-85-6
Molecular Formula: C70H92ClN17O14
N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2 - Names and Identifiers
| Name | Cetrorelix |
| Synonyms | CETRORELIX Cetrorelix Cetrorelixum CETRORELIX ACID Cetrorelix [INN] Cetrorelix acetate CETRIZINEDIHYDROCHLORIDE Cetrorelixum [inn-latin] AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2 N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide D-alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl- (2S)-N-[(2R)-1-Amino-1-oxopropan-2-yl]-1-[(2S,5S,8R,11S,14S,17R,20R,23R)-2-(3-carbamimidamidopropyl)-8-[3-(carbamoylamino)propyl]-20-(4-chlorobenzyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(2-naphthylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-3,6,9,12,15,18,21,24-octaazahexacosan-1-oyl]pyrrolidine-2-carboxamide (non-preferred name) |
| CAS | 120287-85-6 |
| EINECS | 686-384-6 |
| InChI | InChI=1/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54-,55+,56-,57-,58?/m1/s1 |
N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2 - Physico-chemical Properties
| Molecular Formula | C70H92ClN17O14 |
| Molar Mass | 1431.04 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | >259°C (dec.) |
| Solubility | DMSO (Slightly, Heated), Methanol (Very Slightly) |
| Appearance | White powder |
| Color | White to Off-White |
| pKa | 9.82±0.15(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.667 |
N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2 - Reference Information
| overview | cetrorelix acetate is a synthetic decapeptide, which is mainly used in assisted reproductive technology to prevent early ovulation for patients with controlled ovarian stimulation. cetrorelix acetate is also often called cetrorelix, which is a gonadotropin-releasing hormone (GnRH) antagonist, it can compete with endogenous LHRH to bind receptors on the pituitary cell membrane, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary in a dose-dependent manner. |
| pharmacological effects | cetrorelix acetate is a gonadotropin-releasing hormone (GnRH) antagonist. This product competes with endogenous GnRH for receptors on pituitary cells, thereby inhibiting the release of endogenous luteinizing hormone (LH) and follicle stimulating hormone (FSH), delaying the appearance of LH peaks, thereby controlling ovulation. The effect of this product is dose-dependent, the inhibitory effect is direct, and it is maintained by continuous treatment, and it does not cause the luteinizing hormone receptor activity to rise at the beginning and then down-regulated. |
| application | cetrorelix acetate is a synthetic decapeptide, which is mainly used in assisted reproductive technology to prevent premature ovulation for patients with controlled ovarian stimulation. cetrorelix acetate is also often called cetrorelix, which is a gonadotropin-releasing hormone (GnRH) antagonist, it can compete with endogenous LHRH to bind receptors on the pituitary cell membrane, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary in a dose-dependent manner. |
| detection method | step 1, weigh cetrorrik acetate, dissolve with acetonitrile, dilute with acetonitrile and sulfate buffer solution to prepare impurity reference substance solution; Step 2, weigh cetrorrik acetate, add acetonitrile to dissolve, and dilute with acetonitrile and sulfate buffer solution, prepare a solution containing cetrorelix; step 3, take the impurity reference solution and the test solution respectively and inject it into the liquid chromatograph, record the chromatogram, and calculate the content of each impurity by the peak area according to the external standard method; this method Effectively solve the problem of separating the related substances of its preparation. This method has strong specificity and good repeatability, and can ensure the controllability of the related substances in its preparation. |
| effect | cetrorelix acetate (cetrorelixAcetate), also commonly known as cetrorelix, is an effective progesterone releasing hormone inhibin (LH-RH) receptor antagonist, which can control ovarian stimulation, prevent premature discharge of immature follicles and help conception, so it is often used as a preparation for injection. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov provided (external link) |
Last Update：2024-04-09 21:11:58
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View History
N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2
1-(2-Lauroylaminoethyl)-2-butyl-2-imidazoline
AKOS B001273
2171029-25-5
30005-15-3
142333-36-6
(+)-trans-methylenecyclopropane-2,3-dicarboxamide
2-(Phenylthio)benzyl chloride
321695-37-8
1-Ethyl-6-methoxy-1,2,3,4-tetrahydroquinoline
1-(2-Lauroylaminoethyl)-2-butyl-2-imidazoline
AKOS B001273
2171029-25-5
30005-15-3
142333-36-6
(+)-trans-methylenecyclopropane-2,3-dicarboxamide
2-(Phenylthio)benzyl chloride
321695-37-8
1-Ethyl-6-methoxy-1,2,3,4-tetrahydroquinoline