Molecular Formula | C14H23N3O3S |
Molar Mass | 313.42 |
Density | 1.205±0.06 g/cm3(Predicted) |
pKa | 7.43±0.10(Predicted) |
In vitro study | Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K + current (IC 50 =25 μM). |
biological activity | Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide inhibited the delayed rectifier potassium channel (K current) with an IC50 of 25 μm in a concentration-dependent manner. Sematilide is a Class III antiarrhythmic agent. |
Target | IC50: 25 μm (K current) |
Animal Model: | Mongrel dogs of either sex (10-18 kg body weight) |
Dosage: | 0.3, 1, 3, and 10 mg/kg |
Administration: | I.v. infusions |
Result: | Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg. |