N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐
PJ34 HCl
CAS: 344458-15-7
Molecular Formula: C17H17N3O2HCl
N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐 - Names and Identifiers
N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐 - Physico-chemical Properties
| Molecular Formula | C17H17N3O2HCl |
| Molar Mass | 331.8 |
| Solubility | H2O: soluble22mg/mL |
| Appearance | White solid |
| Color | white to yellow |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| Sensitive | Light Sensitive & Hygroscopic |
| Use | PJ34 HCl is a hydrochloride form of PJ34 and is a PARP inhibitor with EC50 of 20 nM, which is equally effective on PARP1/2. |
| In vitro study | PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M. |
| In vivo study | To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice. |
N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29339900 |
N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.014 ml | 15.069 ml | 30.139 ml |
| 5 mM | 0.603 ml | 3.014 ml | 6.028 ml |
| 10 mM | 0.301 ml | 1.507 ml | 3.014 ml |
| 5 mM | 0.06 ml | 0.301 ml | 0.603 ml |
Last Update：2024-01-02 23:10:35
N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐 - Reference Information
| biological activity | PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 values of 110 nM and 86 nM, respectively. |
Last Update：2024-04-09 21:54:55
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View History
N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐
N-(5-chloro-4-methoxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)benzamide
Asp-Leu-Arg-Val-Asp-Thr-Lys-Ser-Arg-Ala-Ala-Trp-Ala-Arg-Leu-Leu-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-
calcium dihydroxide
1-(((2,5-Dioxopyrrolidin-1-yl)oxy)(pyrrolidin-1-yl)methylene)pyrrolidin-1-ium hexafluorophosphate(V)
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE
2-(2-氟-3,4-二甲氧基苯基)乙酸
1-(5-溴噻唑-2-基)哌嗪
N-Phenyl-2-phenylthiocarbamoyl-2-(2-pyridyl)thioacetamide
4-乙酰胺基苯(甲)酰氯
N-(5-chloro-4-methoxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)benzamide
Asp-Leu-Arg-Val-Asp-Thr-Lys-Ser-Arg-Ala-Ala-Trp-Ala-Arg-Leu-Leu-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-
calcium dihydroxide
1-(((2,5-Dioxopyrrolidin-1-yl)oxy)(pyrrolidin-1-yl)methylene)pyrrolidin-1-ium hexafluorophosphate(V)
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE
2-(2-氟-3,4-二甲氧基苯基)乙酸
1-(5-溴噻唑-2-基)哌嗪
N-Phenyl-2-phenylthiocarbamoyl-2-(2-pyridyl)thioacetamide
4-乙酰胺基苯(甲)酰氯