N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide
COX-1 Inhibitor IV
CAS: 1011244-68-0
Molecular Formula: C13 H10 F3 N3 O
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide - Names and Identifiers
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide - Physico-chemical Properties
| Molecular Formula | C13 H10 F3 N3 O |
| Molar Mass | 281.23 |
| Density | 1.425±0.06 g/cm3(Predicted) |
| Boling Point | 360.8±42.0 °C(Predicted) |
| Solubility | DMSO: 10 mg/mL;ethanol: 5 mg/mL |
| Appearance | Off-white solid |
| pKa | 11.02±0.70(Predicted) |
| Storage Condition | +2C to +8C |
| In vitro study | TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC 50 of 0.8 μM, while that against COX-2 is over 200 μM. |
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.556 ml | 17.779 ml | 35.558 ml |
| 5 mM | 0.711 ml | 3.556 ml | 7.112 ml |
| 10 mM | 0.356 ml | 1.778 ml | 3.556 ml |
| 5 mM | 0.071 ml | 0.356 ml | 0.711 ml |
Last Update：2024-01-02 23:10:35
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide - Reference Information
| biological activity | TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) it is a cell-permeable selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 value of 0.8 μm. |
| Target | Value |
| COX-1 (Cell-free assay) | 0.8 μM |
Last Update：2024-04-09 15:16:56
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Product Name: TFAP Visit Supplier Webpage Request for quotationCAS: 1011244-68-0
Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: TFAP Visit Supplier Webpage Request for quotationCAS: 1011244-68-0
Tel: +86-400-900-4166
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QQ: 2881950922
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Tel: +86-18821248368
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Mobile: +86-18821248368
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View History
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide
NSC 11867
4-(6-Bromoimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
3,3-dichloroazepan-2-one
Ethyl 4-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}carbonyl)-5-methylisoxazole-3-carboxylate 97%
3-(2-chlorophenyl)-3-oxo-2-(phenylhydrazono)propanenitrile
88639-60-5
1-[1-(propan-2-yl)-1H-1,2,3-triazol-4-yl]ethan-1-ol
tert-Butyl 2-(methoxymethyl)azetidine-1-carboxylate
352336-21-1
NSC 11867
4-(6-Bromoimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
3,3-dichloroazepan-2-one
Ethyl 4-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}carbonyl)-5-methylisoxazole-3-carboxylate 97%
3-(2-chlorophenyl)-3-oxo-2-(phenylhydrazono)propanenitrile
88639-60-5
1-[1-(propan-2-yl)-1H-1,2,3-triazol-4-yl]ethan-1-ol
tert-Butyl 2-(methoxymethyl)azetidine-1-carboxylate
352336-21-1