N-(4-氯-3-氰基-7-乙氧基喹啉-6-基)乙

N-(4-氯-3-氰基-7-乙氧基喹啉-6-基)乙

N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide

CAS: 848133-76-6

Molecular Formula: C14H12ClN3O2

N-(4-氯-3-氰基-7-乙氧基喹啉-6-基)乙 - Names and Identifiers

Name	N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide
Synonyms	N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) 4-chloro-3-cyano-7-ethoxy-6-N-acetylquinoline N-(4-Chlor-3-cyan-7-ethoxychinolin-6-yl)acetamid N-(4-CHLORO-3-CYANO-7-ETHOXY-6-QUINOLINYL) ACETAMI N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide N-(4-CHLORO-3-CYANO-7-ETHOXYQUINOLINE-6-YL)ACETAMIDE n-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 4-Chloro-3-cyano-7-ethoxy-6-(N-acetylamino)quinoline acetamide, N-(4-chloro-3-cyano-7-ethoxy-6-quinolinyl)- Acetamide, N-(4-chloro-3-cyano-7-ethoxy-6-quinolinyl)- N-(4-chloro-3-cyano-7-ethoxy-1,4-dihydroquinolin-6-yl)acetamide
CAS	848133-76-6
EINECS	1592732-453-0
InChI	InChI=1/C14H12ClN3O2/c1-3-20-13-5-11-10(4-12(13)18-8(2)19)14(15)9(6-16)7-17-11/h4-5,7H,3H2,1-2H3,(H,18,19)

N-(4-氯-3-氰基-7-乙氧基喹啉-6-基)乙 - Physico-chemical Properties

Molecular Formula	C14H12ClN3O2
Molar Mass	289.72
Density	1.35±0.1 g/cm3(Predicted)
Melting Point	250°C(lit.)
Boling Point	518.6±45.0 °C(Predicted)
Flash Point	267.5°C
Solubility	DMSO (Slightly, Heated)
Vapor Presure	7.35E-11mmHg at 25°C
Appearance	Solid
Color	Light Yellow
pKa	13.13±0.43(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.624

N-(4-氯-3-氰基-7-乙氧基喹啉-6-基)乙 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

N-(4-氯-3-氰基-7-乙氧基喹啉-6-基)乙 - Reference Information

Introduction	N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide is a pale yellow solid that can be dissolved in dimethyl sulfoxide. N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide is a quinoline derivative, which is a synthetic drug of nerynx/neratinib. The key intermediates.
Use	N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide can be used as a pharmaceutical intermediate and an intermediate in organic synthesis, such as the synthesis of the drug molecule lenatinib. Lenatinib as a subsequent intensive adjuvant therapy containing trastuzumab for early HER2-positive (human epidermal growth factor receptor 2-positive) overexpressed or amplified breast cancer in adult patients.
synthetic method	N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) the carbonyl precursor of Acetamide (61g, 0.22 mol) and N,N-lutidine (0.85g, 5 mol%) were suspended in ethyl acetate (565 mL). The mixture was stirred at room temperature. Trichlorophosphine oxide (60 mL, 0.65 mol) was added slowly to the mixture over 1 H. The mixture was heated at reflux for 2 H to obtain a clear solution and the mixture was cooled to room temperature. The reaction solution was slowly poured into ice water (900 mL) and stirred for 1 H, the resulting solid was washed with water (80 mL x 2) and dried, the crude product (60g) suspension in DMF (180 mL) And stirred at room temperature for 1 H, filter the solid, wash the filtrate with ethyl acetate (39 mL x 3), the target product, N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide, was obtained by drying at 50°C .

Last Update：2024-04-10 22:29:15

N-(4-氯-3-氰基-7-乙氧基喹啉-6-基)乙

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Product Name: N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide Visit Supplier Webpage Request for quotation
CAS: 848133-76-6
Tel: +86-400-900-4166
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QQ: 2881950922

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Product Name: N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide Visit Supplier Webpage Request for quotation
CAS: 848133-76-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: n-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide Visit Supplier Webpage Request for quotation
CAS: 848133-76-6
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