N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺
FK962
CAS: 283167-06-6
Molecular Formula: C14H17FN2O2
N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺 - Names and Identifiers
| Name | FK962 |
| Synonyms | FK962 N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro- |
| CAS | 283167-06-6 |
N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺 - Physico-chemical Properties
| Molecular Formula | C14H17FN2O2 |
| Molar Mass | 264.3 |
| Storage Condition | Sealed in dry,Room Temperature |
| Use | FK962 is an enhancer of somatostatin (somatostatin) release and has a cognitive enhancing effect. |
| In vitro study | FK962 (1 nM-1 μM) significantly enhances high K + -evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca 2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp. |
| In vivo study | FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease. Animal Model: Male Lister Hooded rats, weighing approximately 270-300 Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered i.p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |
N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.784 ml | 18.918 ml | 37.836 ml |
| 5 mM | 0.757 ml | 3.784 ml | 7.567 ml |
| 10 mM | 0.378 ml | 1.892 ml | 3.784 ml |
| 5 mM | 0.076 ml | 0.378 ml | 0.757 ml |
Last Update：2024-01-02 23:10:35
N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺 - In Vivo
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease。
Last Update：2023-08-16 21:32:38
N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺 - Reference Information
| biological activity | FK962 is an enhancer of somatostatin (somatostatin) release and has a cognitive enhancement effect. |
| target | Somatostatin release |
| in vitro study | FK962 (1 nM-1 μM) significantly enhances high K -evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca 2 channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp. |
| in vivo study | FK962 (0.1, 0.3 or 1.0 mg/kg; I. p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease. animal model: male sister hooded rats, weighing approximately 270-300 Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered I. p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |
| Animal Model: | Male Lister Hooded rats, weighing approximately 270-300 |
| Dosage: | 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg |
| Administration: | Administered I .p. |
| Result: | Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |
Last Update：2024-04-09 19:05:04
Supplier List
Spot supply
Product Name: FK962 Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: N-(1-Acetylpiperidin-4-yl)-4-fluorobenzamide Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: FK962 Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: FK962 Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: FK962 Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: N-(1-Acetylpiperidin-4-yl)-4-fluorobenzamide Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: FK962 Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: FK962 Visit Supplier Webpage Request for quotationCAS: 283167-06-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺
(4-((三氟甲基)硫代)苄基)肼
ALPHA-CYCLOPROPYLBENZYL ALCOHOL
双环[2.2.2]辛-7-烯-2,3,5,6-四甲酸二酐
KSCM-5
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
direct yellow 27 (C.I. 13950)
1-环丙基-6,8-二氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸
Methanol,1-[dimethyl(2-phenylethyl)silyl]-, 1-acetate
2-硝基苯胺-4-磺酸钠盐
(4-((三氟甲基)硫代)苄基)肼
ALPHA-CYCLOPROPYLBENZYL ALCOHOL
双环[2.2.2]辛-7-烯-2,3,5,6-四甲酸二酐
KSCM-5
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
direct yellow 27 (C.I. 13950)
1-环丙基-6,8-二氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸
Methanol,1-[dimethyl(2-phenylethyl)silyl]-, 1-acetate
2-硝基苯胺-4-磺酸钠盐