N-(((1R,2R)-2-(2,3-二氢苯并呋喃-4-基)环丙基)甲基)丙酰胺
Tasimelteon
CAS: 609799-22-6
Molecular Formula: C15H19NO2
N-(((1R,2R)-2-(2,3-二氢苯并呋喃-4-基)环丙基)甲基)丙酰胺 - Names and Identifiers
| Name | Tasimelteon |
| Synonyms | MA 1 VEC 162 BMS 214778 tasimelteon Tasimelteon tasimelteon impurity A (1R-trans)-N-[[2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide N-{[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide Tasimelteon (1R-trans)-N-[[2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide |
| CAS | 609799-22-6 |
| InChI | InChI=1/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1 |
N-(((1R,2R)-2-(2,3-二氢苯并呋喃-4-基)环丙基)甲基)丙酰胺 - Physico-chemical Properties
| Molecular Formula | C15H19NO2 |
| Molar Mass | 245.32 |
| Density | 1.145 |
| Melting Point | 78 °C |
| Boling Point | 442.6±24.0 °C(Predicted) |
| Flash Point | 221.448°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 16.43±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.564 |
| In vitro study | Tasimelteon (BMS-214778) has 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (K i =0.0692 nM and K i =0.17 nM in NIH-3T3 and CHO-K1 cells, respectively), than for the MT1 receptor (Ki=0.304 nM and Ki=0.35 nM, respectively). Tasimelteon has no appreciable affinity for more than 160 other pharmacologically relevant receptors and several enzymes. |
N-(((1R,2R)-2-(2,3-二氢苯并呋喃-4-基)环丙基)甲基)丙酰胺 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.076 ml | 20.382 ml | 40.763 ml |
| 5 mM | 0.815 ml | 4.076 ml | 8.153 ml |
| 10 mM | 0.408 ml | 2.038 ml | 4.076 ml |
| 5 mM | 0.082 ml | 0.408 ml | 0.815 ml |
Last Update：2024-01-02 23:10:35
N-(((1R,2R)-2-(2,3-二氢苯并呋喃-4-基)环丙基)甲基)丙酰胺 - Reference Information
| biological activity | Tasim elteon (BMS-214778) is a kind, selective dual melatonin receptor agonist (DMRA). The affinity of Tasimelteon for the MT2 receptor is 2.1-4.4 times that of the MT1 receptor. Tasimelteon is a circadian regulator with potential for Non-24 hour sleep/wake disorders (Non-24). |
| Target | Value |
| MT2 receptor () | 9.8(pKi) |
| MT1 receptor () | 9.45(pKi) |
Last Update：2024-04-09 21:48:26
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View History
N-(((1R,2R)-2-(2,3-二氢苯并呋喃-4-基)环丙基)甲基)丙酰胺
Isoxazolidine, 3-(4-fluorophenyl)-3-(1H-imidazol-1-ylmethyl)-5-phenyl-2-(phenylmethyl)-, cis- (9CI)
rac-3-Octadecanamido-2-Methoxypropan-1-ol Phosphocholine
5-METHOXY-N-(PYRIDIN-4-YLMETHYL)BENZO[D]THIAZOL-2-AMINE
6-氯-1H-吡咯并[2,3-b]吡啶-2-羧酸乙酯
Propanediamide, N1-([1,1'-biphenyl]-3-ylmethyl)-N3-hydroxy-2-[(3-phenoxyphenyl)methyl]-
2-CHLORO-1-[4-[1-(3,4-DIMETHYL-PHENYL)-ETHYL]-PIPERAZIN-1-YL]-ETHANONE
(S)-2-(4-(2-CHLOROPHENOXY)-2-OXO-2,5-DIHYDRO-1H-PYRROL-1-YL)-4-METHYLPENTANOIC ACID
3'-CHLORO-5'-(TRIFLUOROMETHOXY)ACETOPHENONE
ALKALINE-IODIDE-AZIDE, ALSTERBERG
Isoxazolidine, 3-(4-fluorophenyl)-3-(1H-imidazol-1-ylmethyl)-5-phenyl-2-(phenylmethyl)-, cis- (9CI)
rac-3-Octadecanamido-2-Methoxypropan-1-ol Phosphocholine
5-METHOXY-N-(PYRIDIN-4-YLMETHYL)BENZO[D]THIAZOL-2-AMINE
6-氯-1H-吡咯并[2,3-b]吡啶-2-羧酸乙酯
Propanediamide, N1-([1,1'-biphenyl]-3-ylmethyl)-N3-hydroxy-2-[(3-phenoxyphenyl)methyl]-
2-CHLORO-1-[4-[1-(3,4-DIMETHYL-PHENYL)-ETHYL]-PIPERAZIN-1-YL]-ETHANONE
(S)-2-(4-(2-CHLOROPHENOXY)-2-OXO-2,5-DIHYDRO-1H-PYRROL-1-YL)-4-METHYLPENTANOIC ACID
3'-CHLORO-5'-(TRIFLUOROMETHOXY)ACETOPHENONE
ALKALINE-IODIDE-AZIDE, ALSTERBERG