Mps1-IN-3
Mps1-IN-3
CAS: 1609584-72-6
Molecular Formula: C26H31N7O4S
Mps1-IN-3 - Names and Identifiers
Mps1-IN-3 - Physico-chemical Properties
| Molecular Formula | C26H31N7O4S |
| Molar Mass | 537.63 |
| Density | 1.407±0.06 g/cm3(Predicted) |
| Boling Point | 890.3±75.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 10.35±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC 50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC 50 of appr 5 µM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint. |
| In vivo study | Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity. |
Mps1-IN-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 46 - If swallowed, seek medical advice immediately and show this container or label. |
Mps1-IN-3 - Reference Information
| biological activity | Mps1-IN-3 is a potent, selective MPS1 inhibitor with an IC50 value of 50 nM. |
| Target | Mps1 50 nM (IC 50 ) |
| in vitro study | Mps1-IN-3 is a pot MPS1 kinase inhibitor, with an IC 50 of 50 nM. Mps1-IN-3 inhibit the propagation of U251 gliobastoma cells with an IC 50 of appr 5 µm. Mps1-IN-3 (2 μm) can complete abrogates checkpoint. |
| in vivo study | Mps1-IN-3 (2 mg/kg, I. v.) sensitizes gliobastoma cells in murine tumor models, with prolongated survival and no toxicity. |
Last Update：2024-04-09 21:21:28
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View History
Mps1-IN-3
1-Azabicyclo[2.2.2]octane-3-carboxylic acid
外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺
{[(4-硝基苯基)甲基]硫烷基}甲亚酰胺氢溴酸盐
N-({[1-(1-ADAMANTYL)ETHYL]AMINO}CARBONOTHIOYL)THIOPHENE-2-CARBOXAMIDE
11-cis-3,4-Didehydro Retinal
5-[2-(乙基巯基)丙基]-3-羟基-2-(丁酰基)-2-环己烯-1-酮
3-METHACRYLOXYPROPYLBIS(TRIMETHYL SILOXY)METHYLSILANE
1,4-伸苯基二丙酸
3-(4-氯苯基)丙炔酸
1-Azabicyclo[2.2.2]octane-3-carboxylic acid
外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺
{[(4-硝基苯基)甲基]硫烷基}甲亚酰胺氢溴酸盐
N-({[1-(1-ADAMANTYL)ETHYL]AMINO}CARBONOTHIOYL)THIOPHENE-2-CARBOXAMIDE
11-cis-3,4-Didehydro Retinal
5-[2-(乙基巯基)丙基]-3-羟基-2-(丁酰基)-2-环己烯-1-酮
3-METHACRYLOXYPROPYLBIS(TRIMETHYL SILOXY)METHYLSILANE
1,4-伸苯基二丙酸
3-(4-氯苯基)丙炔酸