Molnupiravir(MK-4482)

Molnupiravir(MK-4482) - Names and Identifiers

Name	Molnupiravir
Synonyms	Tube994 EIDO-2801 EIDD-2801 Molnupiravir EIDD-2801(EIDD 2801) Molnupiravir(MK-4482) Uridine, 4-oxime, 5'-(2-methylpropanoate) β-D-N4 hydroxycytidine-5'-isopropyl ester ((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
CAS	2349386-89-4
EINECS	604-604-1

Molnupiravir(MK-4482) - Physico-chemical Properties

Molecular Formula	C13H19N3O7
Molar Mass	329.31
Density	1.115±0.06 g/cm3(Predicted)
Melting Point	156 - 159°C
Boling Point	582.6±50.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
Storage Condition	-20°C, Inert atmosphere
Use	It is a key intermediate in the preparation of Sacubitril

Molnupiravir(MK-4482) - Introduction

Molnupiravir (EIDD-2801) is an orally bioavailable isopropyl ester prodrug in the EIDD-1931 of a ribonucleoside analog. Molnupiravir show a wide range of activities against influenza viruses and coronaviruses such as SARS-CoV-2,MERS-CoV, and SARS-CoV. Molnupiravir have the potential for COVID-19 and seasonal, pandemic influenza.

Last Update：2023-08-16 23:22:23

Molnupiravir(MK-4482) - biological activity

Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza

Last Update：2023-08-16 23:22:23

Molnupiravir(MK-4482) - Vivo study

Molnupiravir (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease.
Molnupiravir (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever.

Animal Model:	C57BL/6 mice (intranasal infection with SARS-CoV)
Dosage:	50, 150, 500 mg/kg
Administration:	Oral; every 12 hours for 3 days
Result:	Body weight loss is significantly diminished or prevented.

Animal Model:	Ca/09-infected female ferrets
Dosage:	7 mg/kg
Administration:	Oral; twice daily for 3.5 days
Result:	Shed virus load and duration of fever were significantly reduced.

Last Update：2023-08-16 23:22:23

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Molnupiravir(MK-4482)

Molnupiravir

CAS: 2349386-89-4

Molecular Formula: C13H19N3O7

Molnupiravir(MK-4482) - Names and Identifiers

Molnupiravir(MK-4482) - Physico-chemical Properties

Molnupiravir(MK-4482) - Introduction

Molnupiravir(MK-4482) - biological activity

Molnupiravir(MK-4482) - Vivo study

Supplier List

Molnupiravir(MK-4482) Request for Quotation

Molnupiravir

CAS: 2349386-89-4

Molecular Formula: C13H19N3O7

Molnupiravir(MK-4482) - Names and Identifiers

Molnupiravir(MK-4482) - Physico-chemical Properties

Molnupiravir(MK-4482) - Introduction

Molnupiravir(MK-4482) - biological activity

Molnupiravir(MK-4482) - Vivo study

Supplier List

Molnupiravir(MK-4482)