Name | Metiamide |
Synonyms | CS-159 Metiamide SKF-92058 MetiaMide HCl MetiaMide hydrochloride 1-Methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]thiourea N-Methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]thiourea 1-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]thiourea |
CAS | 34839-70-8 |
EINECS | 200-258-5 |
Molecular Formula | C9H16N4S2 |
Molar Mass | 244.38 |
Density | 1.245±0.06 g/cm3(Predicted) |
Boling Point | 463.0±55.0 °C(Predicted) |
pKa | 14.14±0.10(Predicted) |
Storage Condition | Sealed in dry,Store in freezer, under -20°C |
In vitro study | Metiamide (SK&F 92058) is a competitive with aldehyde substrates and noncompetitive with the Human E3 Aldehyde Dehydrogenase coenzyme, binding to both the free E3 isozyme and the enzyme·coenzyme binary complex with K i values of 0.92 μM glycolaldehyde as the varied substrate. Data is got as percentage change in GTPase activity induced by metiamide compared with the GTPase activity stimulated by HA (100 μM). |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.092 ml | 20.46 ml | 40.92 ml |
5 mM | 0.818 ml | 4.092 ml | 8.184 ml |
10 mM | 0.409 ml | 2.046 ml | 4.092 ml |
5 mM | 0.082 ml | 0.409 ml | 0.818 ml |