Methylsulfonic Acid
Methanesulfonic acid
CAS: 75-75-2;17696-73-0
Molecular Formula: CH4O3S
Methylsulfonic Acid - Names and Identifiers
| Name | Methanesulfonic acid |
| Synonyms | MSA Mesic acid SULFOMETHANE Methylsulfonic Acid Methylsulphonicacid Methanesulfonic acid Methanesulphonic acid acidemethanesulfonique kyselinamethansulfonova Kyselina methansulfonova Methanesulfonicacidaqsoln iron(2+) dimethanesulfonate |
| CAS | 75-75-2 17696-73-0 |
| EINECS | 200-898-6 |
| InChI | InChI=1/2CH4O3S.Fe/c2*1-5(2,3)4;/h2*1H3,(H,2,3,4);/q;;+2/p-2 |
| InChIKey | AFVFQIVMOAPDHO-UHFFFAOYSA-N |
Methylsulfonic Acid - Physico-chemical Properties
| Molecular Formula | CH4O3S |
| Molar Mass | 96.11 |
| Density | 1.475-1.485 g/mL at 20 °C1.481 g/mL at 25 °C (lit.) |
| Melting Point | 17-19 °C (lit.) |
| Boling Point | 167 °C/10 mmHg (lit.) |
| Flash Point | >230°F |
| Water Solubility | Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins. |
| Solubility | water: soluble1,000 g/L at 20°C |
| Vapor Presure | 1 mm Hg ( 20 °C) |
| Vapor Density | 3.3 (vs air) |
| Appearance | Solution |
| Specific Gravity | 1.48 (18/4℃) |
| Color | brown |
| Maximum wavelength(λmax) | ['λ: 240-320 nm Amax: <0.4'] |
| Merck | 14,5954 |
| BRN | 1446024 |
| pKa | -2.6(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Moisture sensitive. Incompatible with amines, bases, water, common metals. Releases a substantial amount of heat when diluted with water (add acid to water with care if diluting). |
| Sensitive | Light Sensitive & Hygroscopic |
| Refractive Index | n20/D 1.429(lit.) |
| Physical and Chemical Properties | Colored or slightly brown oily liquid, solid at low temperature. The melting point of 20 deg C, boiling point of 167 deg C (13.33kPa),122 deg C (0.133kPa). Relative density 1.4812(18 degrees C), refractive index 1.4317(16 degrees C). Soluble in water, alcohol and ether, insoluble in alkanes, benzene, toluene, etc., the boiling water, hot alkali solution does not decompose, the metal iron, copper and lead have a strong corrosive effect. |
| Use | Used as solvent, alkylation, esterification and polymerization catalyst, also used in pharmaceutical and electroplating industry |
Methylsulfonic Acid - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R22 - Harmful if swallowed R21/22 - Harmful in contact with skin and if swallowed. R35 - Causes severe burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S1/2 - Keep locked up and out of the reach of children. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 1 |
| RTECS | PB1140000 |
| TSCA | Yes |
| HS Code | 29041000 |
| Hazard Class | 8 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 649 mg/kg LD50 dermal Rabbit 200 - 2000 mg/kg |
Methylsulfonic Acid - Upstream Downstream Industry
| Raw Materials | Methyl disulfide Methanesulfonyl chloride |
| Downstream Products | Methanesulfonic anhydride Sodium trifluoromethanesulfonate Fluconazole Phentolamine Mesylate |
Methylsulfonic Acid - Nature
Open Data Verified Data
colorless or slightly brown oily liquid, solid at low temperature. Relative density 1. 4812 (18 ℃), melting point 20 ℃, boiling point 167 ℃(13. 33kPa), refractive index 1. 4317 (16 ℃). Soluble in water, alcohol and ether, insoluble in alkanes, benzene, toluene, etc., the hot water, hot alkali solution does not decompose, the metal iron, copper and lead have a strong corrosive effect.
Last Update：2024-01-02 23:10:35
Methylsulfonic Acid - Safety
Open Data Verified Data
- This product has a strong stimulating effect on the skin and mucous membranes, but the toxicity of the two is small.
- This product is packaged in 250kg plastic drum or steel plastic drum. Store in a cool, ventilated room. Keep away from fire and heat source. With oxidant, alkali Isolation storage and transportation.
Last Update：2022-01-01 10:38:00
Methylsulfonic Acid - Use
Open Data Verified Data
methanesulfonic acid is a raw material for pharmaceuticals and pesticides, and can also be used as a dehydrating agent, a coating curing Accelerator, a fiber treatment agent, and the like.
Last Update：2022-01-01 10:38:00
Methylsulfonic Acid - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| methyl sulfonate electroplating solution | methyl sulfonic acid is a caustic chemical substance, abbreviated as MSA, it has a wide application prospect in the field of electroplating and has been proved to be a good substitute for fluoroboric acid or phenol sulfonic acid. methyl sulfonate electroplating solution has been applied to tin and tin-lead alloy electroplating, product features are as follows: 1. Bright pure tin plating of methyl sulfonic acid type, the crystal of the coating is fine, uniform, bright silver white, with good weldability, suitable for the electronics industry. 2. The plating solution has high plating speed, wide current density range, fast deposition speed and excellent deep plating ability. 3. After standard aging test or long-term storage, good welding performance can be maintained. 4. Does not contain fluorine boric acid, wastewater treatment is easy, low corrosion, conducive to environmental protection. |
| Application | methane sulfonic acid is a raw material for medicines and pesticides, and can also be used as dehydrating agent, coating curing accelerator, fiber treatment agent, solvent, catalysts for polymerization, esterification and polymerization. used as catalyst used as solvent, alkylation, esterification and polymerization catalyst, also used in pharmaceutical and electroplating industry used as esterification catalyst, alkylating agent, and for oxidation reactions. catalysts for alkylation, esterification and polymerization. Solvent. can be used in pharmaceutical intermediates, electroplating, organic synthesis intermediates used as solvents and catalysts for alkylation, esterification and polymerization reactions, pharmaceutical intermediates, 70% concentration for electroplating. |
| production method | is obtained from the oxidation of methyl thiocyanate by nitric acid. The nitric acid and the effective negative water are carefully heated to 80-88 °c, methyl thiocyanate is added in portions, and the temperature is automatically increased to about 105 °c. After the reaction was relieved, the reaction was heated to 120 ° C. And reacted for 5 hours to obtain a crude product. The crude product was diluted with exchange water, adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered. The filtrate was deeply condensed to the extent that crystals were precipitated, and the crystals were washed with methanol to remove nitrate to obtain barium methanesulfonate. Then, the base was added to the exchange water, boiled, decomposed by hot addition of sulfuric acid, filtered, and the filtrate was concentrated under reduced pressure until no water was produced, to obtain a finished product. Another method is from methylisothiourea sulfate by chlorination, oxidation, hydrolysis and derived. Adding methylisothiourea sulfate into water, passing chlorine gas at 20-25 ℃, until the color of the solution turns yellow, and the phenomenon of oil layer, temperature drop and large amount of residual chlorine discharge in the exhaust pipe appears at the bottom of the bottle, the end point of the reaction. The reaction solution was extracted with chloroform, the extract was dried, chloroform was distilled off at 60-62 ° C. Under normal pressure, and then distilled under reduced pressure to collect a 60-65 ° C. (2.67kPa) fraction to obtain methanesulfonyl chloride. The base was added dropwise with stirring to hot water at 80 ° C., and the hydrolysis was maintained for about 2H until the oil droplets in the reaction solution disappeared. The reaction solution was concentrated to syrup under reduced pressure and diluted with water, Further, the mixture was concentrated under reduced pressure until no water was distilled to obtain methanesulfonic acid. |
| category | corrosive article |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LDL0: 200 mg/kg |
| flammability hazard characteristics | flammable; Thermally decomposed toxic formaldehyde and sulfur dioxide smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from oxidants and alkalis. |
| fire extinguishing agent | Sand, foam, water mist |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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View History
Methylsulfonic Acid
1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(5-nitro-1-naphthalenyl)-
5-(4-chlorobenzyl)-1H-pyrazolo[3,4-d]pyriMidin-4(5H)-one
339023-37-9
5908-54-3
197143-34-3
1,3-二溴-2,2-二甲氧基丙烷
321433-65-2
5H-Thiazolo[3,2-a]pyrimidine-6-carbonitrile, 7-(4-chlorophenyl)-2,3-dihydro-5-oxo-
Pseudourea,2-(5-phenylpentyl)-2-thio-,monohydrochloride
1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(5-nitro-1-naphthalenyl)-
5-(4-chlorobenzyl)-1H-pyrazolo[3,4-d]pyriMidin-4(5H)-one
339023-37-9
5908-54-3
197143-34-3
1,3-二溴-2,2-二甲氧基丙烷
321433-65-2
5H-Thiazolo[3,2-a]pyrimidine-6-carbonitrile, 7-(4-chlorophenyl)-2,3-dihydro-5-oxo-
Pseudourea,2-(5-phenylpentyl)-2-thio-,monohydrochloride
Raw Materials for Methylsulfonic Acid
Downstream Products for Methylsulfonic Acid