Mavacoxibd
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE
CAS: 170569-88-7
Molecular Formula: C16H11F4N3O2S
Mavacoxibd - Names and Identifiers
Mavacoxibd - Physico-chemical Properties
| Molecular Formula | C16H11F4N3O2S |
| Molar Mass | 385.34 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Melting Point | 167-169°C |
| Boling Point | 519.8±60.0 °C(Predicted) |
| Solubility | DMSO |
| Appearance | Solid |
| Color | Off-White to Pale Beige |
| pKa | 9.67±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Use | Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity. |
| Target | COX-2 |
| In vivo study | Osteoarthritic dogs enrolled in the studies are randomized to receive treatment with Mavacoxib and daily placebo for carprofen or placebo for Mavacoxib and daily carprofen at a nominal dose of 4 mg/kg BW. Mavacoxib is administered in both studies with a 2-week interval between the first and second doses but with monthly dosing thereafter. The nominal Mavacoxib doses in Studies 1 and 2 are 4 and 2 mg/kg BW, respectively. Seven Mavacoxib doses are administered in Study 1, but only five doses in Study 2. In Study 1, Mavacoxib is administered without regard to the timing of meals, but in Study 2, all of the Mavacoxib doses are administered with food. |
Mavacoxibd - Reference
| Reference Show more | 1. Hurst EA, et al. The selective cyclooxygenase-2 inhibitor mavacoxib (Trocoxil) exerts anti-tumour effects in vitro independent of cyclooxygenase-2 expression levels. Vet Comp Oncol. 2019 Jun;17(2):194-207.2. Cox SR, et al. Population pharmacokinetics of mavacoxib in osteoarthritic dogs. J Vet Pharmacol Ther. 2011 Feb;34(1):1-11. |
Mavacoxibd - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.595 ml | 12.976 ml | 25.951 ml |
| 5 mM | 0.519 ml | 2.595 ml | 5.19 ml |
| 10 mM | 0.26 ml | 1.298 ml | 2.595 ml |
| 5 mM | 0.052 ml | 0.26 ml | 0.519 ml |
Last Update：2024-01-02 23:10:35
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View History
Mavacoxibd
培哚普利杂质16
3-甲氧基异噻唑-4-胺盐酸盐
苯基(嘧啶-4-基)甲酮
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3-甲基噻吩-2-甲醛
磷酸葡萄糖异构酶 来源于嗜热脂肪芽胞杆菌
培哚普利杂质16
3-甲氧基异噻唑-4-胺盐酸盐
苯基(嘧啶-4-基)甲酮
2-氯苯并噁唑
2-[(4-CHLOROPHENYL)SULFINYL]-4,6-DIMETHYL-3-(PHENYLSULFONYL)PYRIDINE
4-(吡啶-2-基甲基)苯胺
2-Imidazolidinone, 4-phenyl-1-[2-(propylthio)ethyl]-
3-甲基噻吩-2-甲醛
磷酸葡萄糖异构酶 来源于嗜热脂肪芽胞杆菌