MP412
AV-412
CAS: 451493-31-5
Molecular Formula: C41H44ClFN6O7S2
MP412 - Names and Identifiers
MP412 - Physico-chemical Properties
| Molecular Formula | C41H44ClFN6O7S2 |
| Molar Mass | 851.4054632 |
| Solubility | DMSO: ≥ 28 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | AV-412 inhibits autophosphorylation of EGFR and ErbB2 with IC 50 of 43 and 282 nM, respectively. AV-412 also inhibits epidermal growth factor (EGF)-dependent cell proliferation with an IC 50 of 100 nM. AV-412 abrogates EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. |
| In vivo study | In animal studies using cancer xenograft models, AV-412 (30 mg/kg) demonstrates complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively. AV-412 suppresses autophosphorylation of EGFR and ErbB2 at the dose corresponding to its antitumor efficacy. When various dosing schedules are applied, AV-412 shows significant effects with daily and every-other-day schedules, but not with a once-weekly schedule, suggesting that frequent dosing is preferable for this compound. Furthermore, AV-412 shows a significant antitumor effect on the ErbB2-overexpressing breast cancer KPL-4 cell line, which is resistant to gefitinib. |
MP412 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.175 ml | 5.873 ml | 11.745 ml |
| 5 mM | 0.235 ml | 1.175 ml | 2.349 ml |
| 10 mM | 0.117 ml | 0.587 ml | 1.175 ml |
| 5 mM | 0.023 ml | 0.117 ml | 0.235 ml |
Last Update：2024-01-02 23:10:35
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Product Name: AV-412 Visit Supplier Webpage Request for quotationCAS: 451493-31-5
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CAS: 451493-31-5
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CAS: 451493-31-5
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View History
MP412
2-chloro-3,5-dimethylpyridine
2(3H)-Furanone, dihydro-5-phenyl-4-(phenylthio)-
6-Iodo-8-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Linotroban
Fluroxypyr-1-methylheptyl Ester
Cyclopropanecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, (1R,2R)-rel-
N-(Aminoethyl)-5-naphthylamine-1-sulfonic Acid
Vat Blue 18
N-[5-(5-ethyl-1,3-benzoxazol-2-yl)-2-methylphenyl]-2-methoxybenzamide
2-chloro-3,5-dimethylpyridine
2(3H)-Furanone, dihydro-5-phenyl-4-(phenylthio)-
6-Iodo-8-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Linotroban
Fluroxypyr-1-methylheptyl Ester
Cyclopropanecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, (1R,2R)-rel-
N-(Aminoethyl)-5-naphthylamine-1-sulfonic Acid
Vat Blue 18
N-[5-(5-ethyl-1,3-benzoxazol-2-yl)-2-methylphenyl]-2-methoxybenzamide