MLN-7243
methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate
CAS: 1450833-55-2
Molecular Formula: C19H20F3N5O5S2
MLN-7243 - Names and Identifiers
MLN-7243 - Physico-chemical Properties
| Molecular Formula | C19H20F3N5O5S2 |
| Molar Mass | 519.52 |
| Density | 1.75±0.1 g/cm3(Predicted) |
| pKa | 9.35±0.70(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | TAK-243 treatment resulted in depletion of cellular ubiquitination conjugates, resulting in disruption of signal transduction, induction of Protein toxicity stress, impaired cell cycle progression, and DNA damage repair pathways. TAK-243 has only a weak inhibitory effect on other closely related E1 ubiquitin-like activating enzymes, such as Fat10 activating enzyme, NEDD8 activating enzyme, SUMO activating enzyme, ISG15 activating enzyme and autophagy activating enzyme, its inhibitory activity was weaker than that of UAE. TAK-243 can inhibit the transfer of UAE ubiquitin to E2 enzyme. TAK-243 has an equally potent inhibitory effect on two E1 enzymes that activate ubiquitin (UBA6 and UAE). TAK-243 can significantly inhibit the UAE pathway downstream. However, TAK-243 treatment did not affect the protein levels of UAE(UBE1). A TAK-243 treatment can cause accumulation of short-lived proteins such as c-Jun, c-Myc, MCL1 and p53. |
| In vivo study | In a preliminary study of human xenografts, TAK-243 of the treatments resulted in the death of cancer cells. In a number of solid tumor and hematological tumor models, TAK-243 has a wide range of anti-tumor activity. |
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Product Name: methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate Visit Supplier Webpage Request for quotation
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CAS: 1450833-55-2
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Product Name: MLN7243 Visit Supplier Webpage Request for quotationCAS: 1450833-55-2
Tel: 609-228-6898
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Product Name: TAK-243 Visit Supplier Webpage Request for quotationCAS: 1450833-55-2
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Product Name: methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate Visit Supplier Webpage Request for quotation
CAS: 1450833-55-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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CAS: 1450833-55-2
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View History
MLN-7243
7-nitro-2,4,9-triazabicyclo[4.3.0]nona-3,7,10-triene-5-thione
3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5h-dibenz[b,f]azepine monohydrochloride
1,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
四氯双(四氢呋喃)合铌(IV)
203798-35-0
N,N-dimethyl-N-{4-[6-(3-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]phenyl}amine
1-[1-(2-Fluoro-phenyl)-1H-pyrazol-4-yl]-ethylamine
Lipoxin A4 methyl ester
3-amino-N-(3-chloro-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
7-nitro-2,4,9-triazabicyclo[4.3.0]nona-3,7,10-triene-5-thione
3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5h-dibenz[b,f]azepine monohydrochloride
1,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
四氯双(四氢呋喃)合铌(IV)
203798-35-0
N,N-dimethyl-N-{4-[6-(3-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]phenyl}amine
1-[1-(2-Fluoro-phenyl)-1H-pyrazol-4-yl]-ethylamine
Lipoxin A4 methyl ester
3-amino-N-(3-chloro-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide