MLN-4760
MLN-4760
CAS: 305335-31-3
Molecular Formula: C19H23Cl2N3O4
MLN-4760 - Names and Identifiers
| Name | MLN-4760 |
| Synonyms | MLN-4760 ((S)-1-carboxy-2-(1-(3,5-dichlorobenzyl)-1H-imidazol-5-yl)ethyl)-L-leucine L-Histidine, N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]- |
| CAS | 305335-31-3 |
MLN-4760 - Physico-chemical Properties
| Molecular Formula | C19H23Cl2N3O4 |
| Molar Mass | 428.31 |
| Solubility | DMSO : 100 mg/mL (233.48 mM; Need ultrasonic) |
| Storage Condition | -20℃ |
| Use | MLN-4760 is an effective and selective human ACE2 inhibitor with an IC50 value of 0.44 nM, which is more than 5000 times more selective than other related proteins, including human testicular ACE (IC50,>100 μM) and bovine carboxypeptidase A (IC50,27 μM). |
| Target | Human ACE2; Bovine carboxypeptidase A |
| In vitro study | MLN-4760 is a potent and selective human ACE2 inhibitor (IC 50 , 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes human testicular ACE (IC 50 , >100 μM) and bovine carboxypeptidase A (CPDA; IC 50 , 27 μM). MLN-4760 effectively quenches cleavage of the 7-Mca-YVADAPK(Dnp) in rhACE2. MLN-4760 shows pIC 50 at rhACE2 of 8.5±0.1 and at rhACE of 4.4±0.2. MLN-4760 also shows pIC 50 at rhACE2 of 4.7±0.1, 6.9±0.1 and at ACE of 4.4±0.1, 6.2±0.1 in murine heart and mononuclear cells (MNCs), resepctively. |
| In vivo study | MLN-4760 (100 μM, intracerebroventricular infusion for five days) significantly worsens neurological function at 4 h and 3 d post-stroke without significantly increasing infarct volume. |
MLN-4760 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.335 ml | 11.674 ml | 23.348 ml |
| 5 mM | 0.467 ml | 2.335 ml | 4.67 ml |
| 10 mM | 0.233 ml | 1.167 ml | 2.335 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.467 ml |
Last Update：2024-01-02 23:10:35
MLN-4760 - Reference Information
| biological activity | MLN-4760 (compound 16) is a potent, selective human angiotensin-converting enzyme 2 (ACE2) the IC50 value of the inhibitor was 0.44 nM. MLN-4760 also inhibited bovine carboxypeptidase A (CPDA) with an IC50 value of 27 μm. |
| Target | Value |
| ACE2 (Cell-free assay) | 0.44 nM |
| CPDA (Cell-free assay) | 27 μM |
Last Update：2024-04-09 20:52:54
Supplier List
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Product Name: MLN-4760 Visit Supplier Webpage Request for quotationCAS: 305335-31-3
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Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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Spot supply
Product Name: MLN-4760 Visit Supplier Webpage Request for quotationCAS: 305335-31-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: MLN-4760 Visit Supplier Webpage Request for quotationCAS: 305335-31-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: MLN-4760 Visit Supplier Webpage Request for quotationCAS: 305335-31-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
MLN-4760
3-(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)propanoic acid
2-Chloro-6-Fluorbenzoyl Chloride
1-(2,5-difluorobenzoyl)-4-{[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine
5-(4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl)thiazolidine-2,4-dione
2-Chloro-8-isopropoxyquinazoline
1037082-11-3
1-(2-fluoro-5-methylphenyl)-2-methylbutan-1-ol
405140-31-0
1000576-85-1
3-(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)propanoic acid
2-Chloro-6-Fluorbenzoyl Chloride
1-(2,5-difluorobenzoyl)-4-{[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine
5-(4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl)thiazolidine-2,4-dione
2-Chloro-8-isopropoxyquinazoline
1037082-11-3
1-(2-fluoro-5-methylphenyl)-2-methylbutan-1-ol
405140-31-0
1000576-85-1