Name | 3-Nitrobenzamide |
Synonyms | NSC 37327 BRN 0777185 3-Nitrobenzamide m-Nitrobenzamide N-nitrobenzamide 3-nitro-benzamid m-nitro-benzamid 3-NITROBENZAMIDE M-NITROBENZAMIDE Benzamide, 3-nitro- Benzamide, m-nitro- Benzamide, m-nitro- (8CI) 3-nitrobenzenecarboximidic acid 4-09-00-01061 (Beilstein Handbook Reference) |
CAS | 645-09-0 |
EINECS | 211-431-0 |
InChI | InChI=1/C7H6N2O3/c8-7(10)5-2-1-3-6(4-5)9(11)12/h1-4H,(H2,8,10) |
Molecular Formula | C7H6N2O3 |
Molar Mass | 166.13 |
Density | 1.4994 (rough estimate) |
Melting Point | 140-143 °C (lit.) |
Boling Point | 312.55°C |
Flash Point | 145.852°C |
Vapor Presure | 0mmHg at 25°C |
Appearance | Crystalline Powder or Crystals |
Color | Yellow |
BRN | 777185 |
pKa | 14.86±0.50(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Refractive Index | 1.5880 (estimate) |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | CV5601250 |
TSCA | Yes |
HS Code | 29242990 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Overview | 3-nitrobenzamide, also known as M-nitrobenzamide, is an organic intermediate, it can be prepared from 3-nitrobenzaldehyde or m-nitrobenzonitrile. |
preparation | The general method is as follows: the synthesis of 3-nitrobenzamide refers to the following synthesis of 4-nitrophenol. To a solution of phenol (1mmol) in dichloromethane was added 69% nitric acid (1mmol) and 1mmol transition metal complex ([Co(NH3)5Cl] Cl2), the reaction mixture was stirred at room temperature for 2 hours. The progress of the reaction was monitored by TLC. After completion of the reaction as indicated by TLC, the reaction mixture was treated with sodium carbonate solution. the reaction mixture was extracted with dichloromethane. The organic layer was separated, dried over sodium sulfate and evaporated to give the crude product. The crude product was purified on silica gel to give 4-nitrophenol as the product. 3-nitrobenzamide, yield 82%. |