Molecular Formula | C27H30O15 |
Molar Mass | 594.52 |
Density | 1.76 |
Melting Point | 200°C (dec.) |
Boling Point | 941.7±65.0 °C(Predicted) |
Specific Rotation(α) | -52 (c, 1 in Py) |
Solubility | Soluble in hot methanol, DMSO and other solvents. |
Appearance | Yellow powder |
Color | Off-White to Yellow |
pKa | 6.20±0.40(Predicted) |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
MDL | MFCD03427292 |
Physical and Chemical Properties | Light yellow needle-like crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from sophora rice, safflower. |
In vitro study | For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions. |
In vivo study | At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29389090 |
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biological activity | Kaempferol-3-O-rutinoside (nicotiporin, Nikotoflorin, Kaempferol 3-O-β-rutinoside) is a flavonoid extracted from Carthamus tintorius, it can change the shape and structure of injured neurons, reduce apoptotic cells, down-regulate the expression of p-JAK2, p-STAT3, caspase-3 and Bax, reduce Bax immunoreactivity, and increase Bcl-2 protein expression and immunoreactivity. |
Target | Value |
Use | kaempferol-3-o-rutin has the effects of lowering blood lipid, promoting blood circulation and removing blood stasis. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: hypolipidemic, good dementia symptoms and memory protection |