Name | 1,3,5-Tribromobenzene |
Synonyms | K0337 Tribromobenzene 1,3,5-tribromo-benzen 1,3,5-Tribromobenzene 1,3,5-TRIBROMOBENZENE 1,3,5-tribromo-benzene 1,3,5-tribromo benzene Benzene,1,3,5-tribromo- Phloroglucinol Impurity 27 1,3,5-TRIBROMOBENZENE OEKANAL, 250 MG |
CAS | 626-39-1 |
EINECS | 210-947-3 |
InChI | InChI=1/C6H3Br3/c7-4-1-5(8)3-6(9)2-4/h1-3H |
InChIKey | YWDUZLFWHVQCHY-UHFFFAOYSA-N |
Molecular Formula | C6H3Br3 | ||||
Molar Mass | 314.8 | ||||
Density | 2.3515 (estimate) | ||||
Melting Point | 117-121 °C (lit.) | ||||
Boling Point | 271 °C (lit.) | ||||
Flash Point | 271°C | ||||
Water Solubility | Soluble in hot ethanol and acetic acid. Insoluble in water. | ||||
Solubility | Soluble in ether, benzene and chloroform, slightly soluble in hot ethanol, insoluble in water. | ||||
Vapor Presure | 0.012mmHg at 25°C | ||||
Appearance | Yellow-like solid | ||||
Color | Almost white to orange-brown | ||||
BRN | 1858917 | ||||
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature | ||||
Sensitive | Sensitive to light | ||||
Refractive Index | 1.6340 (estimate) | ||||
MDL | MFCD00000080 | ||||
Physical and Chemical Properties |
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Use | Is an important intermediate in organic synthesis |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R53 - May cause long-term adverse effects in the aquatic environment |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | DC1957200 |
TSCA | Yes |
HS Code | 29036990 |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
preparation | 10mol of benzene is poured into a 500ml three-necked bottle, of chloroform and g of iron powder are added, ice bath to the system is about 0 ° C., protected from light, slowly Dropwise add 35mol liquid bromine and 80ml of chloroform mixed solution, room temperature reaction for 10 hours, a large number of yellow-brown solid precipitation. After completion of the reaction, a saturated aqueous solution of sodium bisulfite was added to remove excess unreacted bromine. The crude product was washed twice with saturated aqueous sodium bisulfite, dried and purified by recrystallization to give a pale yellow-brown powder. |
trait | 1,3,5 tribromobenzene is a pale yellow crystalline solid. |
Use | 1,3,5 tribromobenzene is an intermediate in the manufacture of pharmaceuticals, key Intermediate of 5-trimethoxybenzene application of organic synthesis raw materials is an important intermediate in organic synthesis |
production method | in a 15L round-bottom flask, place 1.1g (mol) of aniline, after 1L of water and 100ml (12.mol) of concentrated hydrochloric acid, the aniline was dissolved and 5L of water was added. The flask was cooled in an ice bath. Then 577g(185mL,3.6mol) of bromine was slowly bubbled in until the solution was significantly yellow in color, which took about 34H, and the reaction was complete. The tribromoaniline was leaked out with Brinell, hydrobromic acid was washed thoroughly with water, and blotted dry. In a 5L flask fitted with a reflux condenser, damp tribromoaniline, 2.1L of 95% ethanol and ML of benzene were placed. The flask was heated on a steam bath to dissolve tribromoaniline. To this solution was added 2.03 of concentrated sulfuric acid and then g (mol) of powdered sodium nitrite was added while the reaction was maintained normal. When the reaction was complete, the solution was heated to boiling and maintained until no more gas had evolved and then allowed to stand in the warm place for another 3 hours. After the mixture had cooled, it was filtered and a solution of 150ml of concentrated sulfuric acid and 1.5L of water was added to the solid. After the excess sodium nitrite had decomposed, it was filtered and the solid was washed with water and then with a small amount of ethanol. The crude dry 1,3, 5-tribromobenzene is red-brown, melting point 112~116 ℃, yield 250 ~ 260g, yield 74% ~ 7 |