Haemanthamine
NSC403140
CAS: 466-75-1
Molecular Formula: C17H19NO4
Haemanthamine - Names and Identifiers
Haemanthamine - Physico-chemical Properties
| Molecular Formula | C17H19NO4 |
| Molar Mass | 301.33706 |
| In vitro study | Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability. Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation. Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress. Cell Viability Assay Cell Line: A2780 ovarian cancer cells Concentration: 1 µM, 10 µM, 50 µM, 100 µM Incubation Time: 24 hours, 48 hours Result: Showed a time- and dose-dependent decrease in cell viability. Cell Proliferation Assay Cell Line: A2780 ovarian cancer cells Concentration: 10 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Led to a significant inhibition of A2780 cell proliferation. |
| In vivo study | A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration. |
Haemanthamine - Introduction
NSC 403140 is an organic compound also known as N-[4-(methylsulfonylphenyl) phenyl]-3,4-dichloroaniline. The following is a description of the nature, use, preparation and safety information of NSC403140:
Nature:
-Appearance: White solid powder
-Molecular formula: C13H10Cl2N2O2S
-Molecular weight: 336.2g/mol
-Melting point: 234-235 ° C
-Solubility: Soluble in organic solvents such as chloroform, dichloromethane and ethanol
Use:
The main use of the NSC403140 is as a chemical reagent. It can be used for sulfurization reaction, cyanation reaction and coupling reaction in organic synthesis reaction. In addition, NSC 403140 is also being studied for the treatment of some diseases, but its use is still being studied.
Preparation Method:
The preparation of NSC403140 includes the following steps:
1. Preparation of methyl benzoate: the reaction of benzyl alcohol with formic acid.
2. Amine (Arbuzov-amine) reaction of methyl formate: methyl benzoate is reacted with trimethyl phosphite to generate quaternary ammonium salt.
3. Sulfurization reaction of quaternary ammonium salt: The quaternary ammonium salt reacts with sodium methanesulfonate dissolved in sodium sulfide to generate NSC403140.
Safety Information:
- NSC403140 should be stored properly, away from light and moisture.
-Wear appropriate protective equipment such as goggles and gloves when handling the NSC403140.
-Avoid inhalation, ingestion or contact with skin. In case of contact, rinse immediately with plenty of water.
-When using NSC403140, please follow safe operating procedures and maintain good laboratory ventilation.
Please note that the safety information of the NSC403140 is based on general understanding only, and the specific safety operation should be determined according to the specific situation and laboratory requirements. Before using the compound, it is best to refer to the relevant safety data sheet and chemical instructions.
Nature:
-Appearance: White solid powder
-Molecular formula: C13H10Cl2N2O2S
-Molecular weight: 336.2g/mol
-Melting point: 234-235 ° C
-Solubility: Soluble in organic solvents such as chloroform, dichloromethane and ethanol
Use:
The main use of the NSC403140 is as a chemical reagent. It can be used for sulfurization reaction, cyanation reaction and coupling reaction in organic synthesis reaction. In addition, NSC 403140 is also being studied for the treatment of some diseases, but its use is still being studied.
Preparation Method:
The preparation of NSC403140 includes the following steps:
1. Preparation of methyl benzoate: the reaction of benzyl alcohol with formic acid.
2. Amine (Arbuzov-amine) reaction of methyl formate: methyl benzoate is reacted with trimethyl phosphite to generate quaternary ammonium salt.
3. Sulfurization reaction of quaternary ammonium salt: The quaternary ammonium salt reacts with sodium methanesulfonate dissolved in sodium sulfide to generate NSC403140.
Safety Information:
- NSC403140 should be stored properly, away from light and moisture.
-Wear appropriate protective equipment such as goggles and gloves when handling the NSC403140.
-Avoid inhalation, ingestion or contact with skin. In case of contact, rinse immediately with plenty of water.
-When using NSC403140, please follow safe operating procedures and maintain good laboratory ventilation.
Please note that the safety information of the NSC403140 is based on general understanding only, and the specific safety operation should be determined according to the specific situation and laboratory requirements. Before using the compound, it is best to refer to the relevant safety data sheet and chemical instructions.
Last Update：2024-04-10 22:29:15
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Product Name: Haemanthamine Visit Supplier Webpage Request for quotationCAS: 466-75-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Haemanthamine Visit Supplier Webpage Request for quotationCAS: 466-75-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
Haemanthamine
4-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)BENZOIC ACIDHYDROCHLORIDE
Benzocyclobutene-1-carboxylic acid methyl ester
2,7-二氮杂螺[4.5]癸烷-2-甲酸, 1,1-二甲基乙酯
A,A-DIFLUOROPHENYLACETIC ACID
N-[3-chloro-4-(4-isobutyryl-1-piperazinyl)phenyl]-2,6-dimethoxybenzamide
4-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)BENZOIC ACIDHYDROCHLORIDE
Benzocyclobutene-1-carboxylic acid methyl ester
2,7-二氮杂螺[4.5]癸烷-2-甲酸, 1,1-二甲基乙酯
A,A-DIFLUOROPHENYLACETIC ACID
N-[3-chloro-4-(4-isobutyryl-1-piperazinyl)phenyl]-2,6-dimethoxybenzamide