Molecular Formula | C59H89N19O13S.C2H4O2 |
Molar Mass | 1364.59 |
Storage Condition | -20°C |
In vitro study | Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors). |
WGK Germany | 3 |
biological activity | Icatibant Acetate is an antagonist of the bradykinin B2 receptor and can be used to treat hereditary angioedema. |
Target | Value |
Animal Model: | Female mice of the CBA/J (H-2 k ) strain. |
Dosage: | 0.06, 0.3, or 1.5 mg/kg. |
Administration: | Subcutaneous administration twice daily. |
Result: | The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening. |