Molecular Formula | C10H23NO5 |
Molar Mass | 237.29 |
Density | 1.077±0.06 g/cm3(Predicted) |
Boling Point | 346.3±32.0 °C(Predicted) |
Solubility | soluble |
pKa | 14.36±0.10(Predicted) |
Storage Condition | -20°C |
In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.214 ml | 21.071 ml | 42.143 ml |
5 mM | 0.843 ml | 4.214 ml | 8.429 ml |
10 mM | 0.421 ml | 2.107 ml | 4.214 ml |
5 mM | 0.084 ml | 0.421 ml | 0.843 ml |
biological activity | NH2-PEG5-OH is a PROTAC linker belonging to the PEG class. NH2-PEG5-OH can be used for the synthesis of PROTAC molecules. NH2-PEG5-OH is also a non-cleavable ADC linker containing 5 units of PEG, which can be used to synthesize antibody conjugated drugs (ADC). |