HC≡C-CH2-PEG2-NH2
2-[2-(2-Propynyloxy)ethoxy]ethylamine
CAS: 944561-44-8
Molecular Formula: C7H13NO2
HC≡C-CH2-PEG2-NH2 - Names and Identifiers
HC≡C-CH2-PEG2-NH2 - Physico-chemical Properties
| Molecular Formula | C7H13NO2 |
| Molar Mass | 143.18 |
| Density | 0.992±0.06 g/cm3(Predicted) |
| Boling Point | 213.8±20.0 °C(Predicted) |
| pKa | 8.72±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.4590 to 1.4630 |
| Physical and Chemical Properties | Bioactive Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-coupled drugs (ADCs). Propargyl-PEG2-amine is a PROTAC linker and belongs to the PEG class. Propargyl-PEG2-NH2 can be used to synthesize a series of PROTAC molecules. |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
HC≡C-CH2-PEG2-NH2 - Risk and Safety
| UN IDs | UN 2735 8/PG II |
| Hazard Class | 8 |
| Packing Group | II |
HC≡C-CH2-PEG2-NH2 - Reference Information
| biological activity | Propargyl-PEG2-amine is a non-cleavable ADC linker for the synthesis of antibody-coupled drugs (ADCs). Propargyl-PEG2-amine is a PROTAC linker and belongs to the PEG class. Propargyl-PEG2-NH2 can be used to synthesize a series of PROTAC molecules. |
| target | Non-cleavable PEGs |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Last Update：2024-04-09 21:04:16
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CAS: 944561-44-8
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