Name | HBDDE |
Synonyms | HBDDE Hhbpdde [1,1'-Biphenyl]-2,2',3,3',4,4'-hexol, 6,6'-bis(methoxymethyl)- |
CAS | 154675-18-0 |
Molecular Formula | C16H18O8 |
Molar Mass | 338.31 |
Melting Point | 165-168℃ |
Appearance | Orange solid. |
Storage Condition | -20°C,惰性气体保护 |
Sensitive | Light Sensitive |
biological activity | HBDDE, a derivative of Ellagic acid, is an isotype selective inhibitor of pkcα and pkcγ, the IC50 values were 43 μm and 50 μm, respectively. The selectivity of HBDDE for PKC alpha/PKC gamma is higher than that of the isozymes PKC Delta, PKC Beta I and PKC Beta II. HBDDE can induce neuronal apoptosis. |
Cell Line: | Cerebellar granule cells |
Concentration: | 50 μM |
Incubation Time: | 5 hours |
Result: | Reduced cell viability significantly by ~70%. |