H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-
CAS: 129121-73-9
Molecular Formula: C138H224N42O41
H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 - Names and Identifiers
H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 - Physico-chemical Properties
| Molecular Formula | C138H224N42O41 |
| Molar Mass | 3127.51 |
| Storage Condition | -20°C |
| In vitro study | CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor. |
| In vivo study | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels. |
H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.32 ml | 1.599 ml | 3.197 ml |
| 5 mM | 0.064 ml | 0.32 ml | 0.639 ml |
| 10 mM | 0.032 ml | 0.16 ml | 0.32 ml |
| 5 mM | 0.006 ml | 0.032 ml | 0.064 ml |
Last Update：2024-01-02 23:10:35
H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 - Reference Information
| biological activity | Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selected CGRP receptor antagonist. |
| target | CGRP receptor |
| in vitro study | CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor. |
| in vivo study | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a pose-dependent manner. The 50 nM pose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basic levels. |
Last Update：2024-04-09 21:54:55
Supplier List
Featured ProductsSpot supply
Product Name: Rat CGRP-(8-37),VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Rat CGRP-(8-37) Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: ALPHA-CGRP (8-37) (RAT) Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL- Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Rat CGRP-(8-37),VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Rat CGRP-(8-37) Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: ALPHA-CGRP (8-37) (RAT) Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL- Visit Supplier Webpage Request for quotationCAS: 129121-73-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
3,7-Anhydro-2-deoxy-7-C-phenyl-D-gulo-heptonic acid delta-lactone
3-乙氧羰基-5-羟基-1-砜基吡唑
2-[[2-(4-Chlorophenyl)-4-thiazolyl]methoxy]-2-methylpropionic acid
RISTOMYCIN MONOSULFATE CRYSTALLIZED
TERT-BUTYL CIS-4-(3-HYDROXYPROPYL)CYCLOHEXYLCARBAMATE
ZIRCONIUM DINITRATE OXIDE HYDRATE
cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole
X-PHOS 2 AMPD
CHEMMAKER CMFS-00344
3,7-Anhydro-2-deoxy-7-C-phenyl-D-gulo-heptonic acid delta-lactone
3-乙氧羰基-5-羟基-1-砜基吡唑
2-[[2-(4-Chlorophenyl)-4-thiazolyl]methoxy]-2-methylpropionic acid
RISTOMYCIN MONOSULFATE CRYSTALLIZED
TERT-BUTYL CIS-4-(3-HYDROXYPROPYL)CYCLOHEXYLCARBAMATE
ZIRCONIUM DINITRATE OXIDE HYDRATE
cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole
X-PHOS 2 AMPD
CHEMMAKER CMFS-00344