In vitro study | The incretin hormone GIP is rapidly degraded in the circulation by dipeptidyl peptidase IV (DPP IV) forming the N-terminally truncated peptide GIP(3-42). |
biological activity | GIP (3-42), human acts as a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist, regulates insulin secretion and GIP metabolism in vivo. |