Molecular Formula | C7H12N2O5 |
Molar Mass | 204.18 |
Density | 1.424±0.06 g/cm3(Predicted) |
Melting Point | ~191℃ |
Boling Point | 586.6±50.0 °C(Predicted) |
pKa | 2.21±0.10(Predicted) |
Storage Condition | -15°C |
In vitro study | gamma-DGG (γ-DGG), a competitive AMPA receptor blocker that blocks less at higher glutamate concentration. At 200-400 μM, gamma-DGG in the bath reduces the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses), and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left. gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory post-synaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p. Quantal analysis shows that the reduction in the e.p.s.p. paralleled the decrease in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.898 ml | 24.488 ml | 48.976 ml |
5 mM | 0.98 ml | 4.898 ml | 9.795 ml |
10 mM | 0.49 ml | 2.449 ml | 4.898 ml |
5 mM | 0.098 ml | 0.49 ml | 0.98 ml |
biological activity | gamma-DGG is a competitive AMPA receptor blocker. |
Target | AMPA receptor |