H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA
4-Chloro-DL-phenylalanine
CAS: 7424-00-2
Molecular Formula: C9H10ClNO2
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA - Names and Identifiers
| Name | 4-Chloro-DL-phenylalanine |
| Synonyms | NSC-77370 Fenclonine H-DL-Phe(4-Cl)-OH DL-4-Chloro-phe-OH 4-chlorophenylalanine Phenylalanine, 4-chloro- Dl-4-Chlorophenylalanine 4-Chloro-DL-phenylalanine DL-Phe(4-Cl)-OH 4-Chloro-DL-Phenylalanine (±)-3-(4-Chlorophenyl)-2-aminopropanoic acid DL-2-Amino-3-(4-chloro-phenyl)-propionic acid H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA |
| CAS | 7424-00-2 |
| EINECS | 231-051-9 |
| InChI | InChI=1/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13) |
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA - Physico-chemical Properties
| Molecular Formula | C9H10ClNO2 |
| Molar Mass | 199.63 |
| Density | 1.2409 (rough estimate) |
| Melting Point | >240°C (dec.)(lit.) |
| Boling Point | 339.5±32.0 °C(Predicted) |
| Water Solubility | slightly soluble |
| Solubility | Aqueous Acid (Slightly), Methanol (Slightly) |
| Appearance | Powder |
| Color | White to almost white |
| BRN | 2805758 |
| pKa | pK1: 2.08(+1);pK2: 8.96(0) (25°C) |
| Storage Condition | room temp |
| Refractive Index | 1.5790 (estimate) |
| MDL | MFCD00002601 |
| In vivo study | 4-Chloro-DL-phenylalanine(PCPA) significantly reduced pulmonary vascular remodeling and pulmonary inflammation induced by MCT (monocrotaline), inhibited Tph-1 and SERT, MMP-2/-9, TIMP-1/-2, IL-1β, TNF-α, expression of ICAM-1. PCPA inhibits 5-HT by inhibiting Tph-1 and regulating SERT and serotonin downstream signaling pathways. |
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AY4390010 |
| TSCA | Yes |
| HS Code | 29224985 |
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA - Reference
| Reference Show more | 1. Zhu-Hong Zheng, renyun Zhao, Yuting Ding, et al. Effects of Baihe Dihuang decoction on behavior and monoamine neurotransmitters in different brain regions of Sleep Initiation and Maintenance Disorders model rats. 2. Fan Fan, Zhang Xin, Jiang Xiqian, Zhang Kaina, AL-MAAMARI Ahmed, Wang Hongying, Zhao Zhenghang. Sedative and hypnotic effects of shumian capsule and its mechanism [J]. Journal of Xi'an Jiaotong University (Medical Sciences),2021,42(01):168-174. |
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | 4-chloro-dl-phenylalazine (fenclonate, PCPA, CP-10188) is a selective irreversible inhibitor of tryptophan hydroxylase. Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine). 4-Chloro-DL-phenylalanine can deplete endogenous serotonin levels. |
| Target | Value |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:49:45
Supplier List
Spot supply
Product Name: 4-Chloro-DL-phenylalanine; PCPA; CP-10188 Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 4-Chloro-DL-phenylalanine Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: 4-Chloro-DL-phenylalanine Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: DL-4-Chlorophenylalanine Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Amino-3-(4-Chlorophenyl)Propionic Acid Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: 4-Chloro-DL-phenylalanine; PCPA; CP-10188 Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 4-Chloro-DL-phenylalanine Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: 4-Chloro-DL-phenylalanine Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: DL-4-Chlorophenylalanine Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Amino-3-(4-Chlorophenyl)Propionic Acid Visit Supplier Webpage Request for quotationCAS: 7424-00-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA
S-182四氢邻苯二甲酸二缩水甘油酯
(-)-辛弗林
KBOPZPXVLCULAV-CBYSEHNBSA-N
(S)-(-)-6,7-二甲氧基-1,2,3,4-四氢异喹啉-3-甲酸盐酸盐
(E)-N'-(2,3,4-三羟基亚苄基)苯甲酰肼
ART-CHEM-BB B001091
S-182四氢邻苯二甲酸二缩水甘油酯
(-)-辛弗林
KBOPZPXVLCULAV-CBYSEHNBSA-N
(S)-(-)-6,7-二甲氧基-1,2,3,4-四氢异喹啉-3-甲酸盐酸盐
(E)-N'-(2,3,4-三羟基亚苄基)苯甲酰肼
ART-CHEM-BB B001091