Dl-4-Chlorophenylalanine
4-Chloro-DL-phenylalanine
CAS: 7424-00-2
Molecular Formula: C9H10ClNO2
Dl-4-Chlorophenylalanine - Names and Identifiers
| Name | 4-Chloro-DL-phenylalanine |
| Synonyms | NSC-77370 Fenclonine H-DL-Phe(4-Cl)-OH DL-4-Chloro-phe-OH 4-chlorophenylalanine Phenylalanine, 4-chloro- Dl-4-Chlorophenylalanine 4-Chloro-DL-phenylalanine DL-Phe(4-Cl)-OH 4-Chloro-DL-Phenylalanine (±)-3-(4-Chlorophenyl)-2-aminopropanoic acid DL-2-Amino-3-(4-chloro-phenyl)-propionic acid H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA |
| CAS | 7424-00-2 |
| EINECS | 231-051-9 |
| InChI | InChI=1/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13) |
Dl-4-Chlorophenylalanine - Physico-chemical Properties
| Molecular Formula | C9H10ClNO2 |
| Molar Mass | 199.63 |
| Density | 1.2409 (rough estimate) |
| Melting Point | >240°C (dec.)(lit.) |
| Boling Point | 339.5±32.0 °C(Predicted) |
| Water Solubility | slightly soluble |
| Solubility | Aqueous Acid (Slightly), Methanol (Slightly) |
| Appearance | Powder |
| Color | White to almost white |
| BRN | 2805758 |
| pKa | pK1: 2.08(+1);pK2: 8.96(0) (25°C) |
| Storage Condition | room temp |
| Refractive Index | 1.5790 (estimate) |
| MDL | MFCD00002601 |
| In vivo study | 4-Chloro-DL-phenylalanine(PCPA) significantly reduced pulmonary vascular remodeling and pulmonary inflammation induced by MCT (monocrotaline), inhibited Tph-1 and SERT, MMP-2/-9, TIMP-1/-2, IL-1β, TNF-α, expression of ICAM-1. PCPA inhibits 5-HT by inhibiting Tph-1 and regulating SERT and serotonin downstream signaling pathways. |
Dl-4-Chlorophenylalanine - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AY4390010 |
| TSCA | Yes |
| HS Code | 29224985 |
Dl-4-Chlorophenylalanine - Reference
| Reference Show more | 1. Zhu-Hong Zheng, renyun Zhao, Yuting Ding, et al. Effects of Baihe Dihuang decoction on behavior and monoamine neurotransmitters in different brain regions of Sleep Initiation and Maintenance Disorders model rats. 2. Fan Fan, Zhang Xin, Jiang Xiqian, Zhang Kaina, AL-MAAMARI Ahmed, Wang Hongying, Zhao Zhenghang. Sedative and hypnotic effects of shumian capsule and its mechanism [J]. Journal of Xi'an Jiaotong University (Medical Sciences),2021,42(01):168-174. |
Dl-4-Chlorophenylalanine - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | 4-chloro-dl-phenylalazine (fenclonate, PCPA, CP-10188) is a selective irreversible inhibitor of tryptophan hydroxylase. Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine). 4-Chloro-DL-phenylalanine can deplete endogenous serotonin levels. |
| Target | Value |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:49:45
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View History
Dl-4-Chlorophenylalanine
1-(4-(4-(2-甲氧基乙氧基)苯基)哌嗪-1-基)乙酮
Silane, [1,4-dioxane-2,3-diylbis(oxy)]bis[trimethyl-, trans-
3-[(E)-[[(1R,2R)-2-[[(1S)-1-[(二甲氨基)羰基]-2,2-二甲基丙基]硫脲基]环己基]亚氨基]甲基]-5-(叔丁基)-4-羟基苯基新戊酸酯
Hexanedioic acid, polymer with 1,4-butanediol, 1,1-methylenebis4-isocyanatobenzene and 1,2-propanediol
2-苯氧基-乙醇二氢磷酸酯二钾盐
2-氨基-2-(3,5-二氯苯基)乙醇盐酸盐
2-苯甲酰基-4-氟苯胺
ART-CHEM-BB B017648
(1-甲基苯并咪唑-2-基)胺
1-(4-(4-(2-甲氧基乙氧基)苯基)哌嗪-1-基)乙酮
Silane, [1,4-dioxane-2,3-diylbis(oxy)]bis[trimethyl-, trans-
3-[(E)-[[(1R,2R)-2-[[(1S)-1-[(二甲氨基)羰基]-2,2-二甲基丙基]硫脲基]环己基]亚氨基]甲基]-5-(叔丁基)-4-羟基苯基新戊酸酯
Hexanedioic acid, polymer with 1,4-butanediol, 1,1-methylenebis4-isocyanatobenzene and 1,2-propanediol
2-苯氧基-乙醇二氢磷酸酯二钾盐
2-氨基-2-(3,5-二氯苯基)乙醇盐酸盐
2-苯甲酰基-4-氟苯胺
ART-CHEM-BB B017648
(1-甲基苯并咪唑-2-基)胺