GW806742X
GW806742X
CAS: 579515-63-2
Molecular Formula: C25H22F3N7O4S
GW806742X - Names and Identifiers
GW806742X - Physico-chemical Properties
| Molecular Formula | C25H22F3N7O4S |
| Molar Mass | 573.55 |
| Density | 1.524±0.06 g/cm3(Predicted) |
| Solubility | DMSO : ≥ 125 mg/mL (217.94 mM) |
| pKa | 10.09±0.60(Predicted) |
| Storage Condition | -20℃ |
| Use | GW806742X is a potent MLKL inhibitor, also a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and has anti-necroptosis activity. GW806742X has activity against VEGFR2. GW806742X blocked necroptosis and IL-33 release in vitro and reduced eosinophilia in Aspergillus fumigatus extract-induced asthma in vivo, an allergic inflammation model that is highly dependent on IL-33. |
| In vitro study | GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM. |
GW806742X - Reference
| Reference Show more | 1: Moreira-Nunes CA, Mesquita FP, Portilho AJS, Mello Júnior FAR, Maués JHDS, Pantoja LDC, Wanderley AV, Khayat AS, Zuercher WJ, Montenegro RC, de Moraes- Filho MO, de Moraes MEA. Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia. Sci Rep. 2020 Dec 4;10(1):21272. doi: 10.1038/s41598-020-78024-8. PMID: 33277547; PMCID: PMC7718893. 2: Shlomovitz I, Erlich Z, Speir M, Zargarian S, Baram N, Engler M, Edry-Botzer L, Munitz A, Croker BA, Gerlic M. Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model. FEBS J. 2019 Feb;286(3):507-522. doi: 10.1111/febs.14738. Epub 2019 Jan 4. PMID: 30576068. 3: Lusthaus M, Mazkereth N, Donin N, Fishelson Z. Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity. Front Immunol. 2018 Feb 23;9:306. doi: 10.3389/fimmu.2018.00306. PMID: 29527209; PMCID: PMC5829068. 4: González-Juarbe N, Gilley RP, Hinojosa CA, Bradley KM, Kamei A, Gao G, Dube PH, Bergman MA, Orihuela CJ. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015 Dec 11;11(12):e1005337. doi: 10.1371/journal.ppat.1005337. PMID: 26659062; PMCID: PMC4676650. |
GW806742X - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.744 ml | 8.718 ml | 17.435 ml |
| 5 mM | 0.349 ml | 1.744 ml | 3.487 ml |
| 10 mM | 0.174 ml | 0.872 ml | 1.744 ml |
| 5 mM | 0.035 ml | 0.174 ml | 0.349 ml |
Last Update：2024-01-02 23:10:35
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Product Name: GW806742X Visit Supplier Webpage Request for quotationCAS: 579515-63-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: GW806742X Visit Supplier Webpage Request for quotationCAS: 579515-63-2
Tel: +86-400-900-4166
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Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: GW806742X Visit Supplier Webpage Request for quotationCAS: 579515-63-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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View History
GW806742X
537017-15-5
Croscarmellose natrium
352690-94-9
3-(5-BroMo-2-Methoxyphenyl)propanenitrile
Strychnin [German]
2(1H)-Quinolinone, 3-amino-4-methyl-
2-(1H-BENZOIMIDAZOL-2-YL)-ETHYLAMINE HCL
40693-49-0
THEAFLAVIN 3-O-GALLATE
537017-15-5
Croscarmellose natrium
352690-94-9
3-(5-BroMo-2-Methoxyphenyl)propanenitrile
Strychnin [German]
2(1H)-Quinolinone, 3-amino-4-methyl-
2-(1H-BENZOIMIDAZOL-2-YL)-ETHYLAMINE HCL
40693-49-0
THEAFLAVIN 3-O-GALLATE