GW0742
GW0742
CAS: 317318-84-6
Molecular Formula: C21H17F4NO3S2
GW0742 - Names and Identifiers
GW0742 - Physico-chemical Properties
| Molecular Formula | C21H17F4NO3S2 |
| Molar Mass | 471.49 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Melting Point | 134.5-135.5 °C |
| Boling Point | 591.5±60.0 °C(Predicted) |
| Solubility | DMSO: >5mg/mL |
| Appearance | solid |
| Color | white |
| pKa | 3.17±0.10(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD07369423 |
| Physical and Chemical Properties | Bioactive GW0742 is a potent, selective PPAR β/δ agonist with an IC50 of 1 nM, which is 1000-fold more selective than hPPAR α and hPPAR γ. |
| Use | Uses GW0742 is a small molecule agonist of the human peroxisome proliferator-activated receptor δ(PPAR δ). It shows an EC50 of 1.1 nM for PPAR δ, which is 100-fold more selective than other human subtypes. |
| In vitro study | In basic cell transcription experiments, GW0742 effectively acted on hPPAR α,hPPAR γ, and hPPAR δ with EC50 of 1.1 μm, 2 μm, and 1 nM, respectively. GW0742 (0.2 μm and 1 μm) significantly increased PPAR β/δ activity in N/TERT-1 keratinocytes. GW0742 (1 μm) significantly inhibited the average cell number of N/TERT-1 keratinocytes. GW0742 (1 M) increased the number of cells in G1 phase, decreased the number of cells in S phase. GW0742 (1 μm) acts on N/TERT-1 keratinocytes and mouse primary keratinocytes to significantly increase mRNA-encoded ADRP, a PPAR β/δ target gene. GW0742 (1 μm) significantly reduced phosphorylation of retinoblastoma (Rb) and p42/44 ERK levels in N/TERT-1 cells. 100 μm GW0742 significantly reduced low KCl-induced neuronal cell death in cerebellar granule neurons. By measuring LDH release, it was observed that 100 μm GW0742 significantly enhanced cell death. Treatment of cerebellar granule neuron medium with 100 μm GW0742 for 6 hours significantly enhanced c-Jun expression. 100 μm GW0742 acts on MCF-7 cells to increase PPARα-mediated transcription in the presence of 1.5% BSA. |
| In vivo study | GW0742 (10 mg/kg) treatment of C57BL6/J mice promoted reverse cholesterol transport. GW0742 (10 mg/kg) treatment of C57BL6/J mice promoted fecal excretion of HDL cholesterol, although there was no effect on HDL cholesterol metabolism. GW0742 acts on the small intestine of mice to reduce the expression of NPC1L1 mRNA. GW0742 (30 mg/kg) treatment of Male BALB/c mice significantly reduced leukocyte recruitment into the lung space prior to induction of LPS-mediated lung inflammation. GW0742 (30 mg/kg) treatment of mouse bronchoalveolar lavage fluid significantly reduced the protein and mRNA levels of proinflammatory cytokines IL-6,IL-1β and TNF-α. |
GW0742 - Risk and Safety
| WGK Germany | 3 |
GW0742 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.121 ml | 10.605 ml | 21.209 ml |
| 5 mM | 0.424 ml | 2.121 ml | 4.242 ml |
| 10 mM | 0.212 ml | 1.06 ml | 2.121 ml |
| 5 mM | 0.042 ml | 0.212 ml | 0.424 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured Products
Product Name: GW0742 Request for quotationCAS: 317318-84-6
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: GW610742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GW0742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: GW0742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: GW0742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: GW0742 Visit Supplier Webpage Request for quotation
CAS: 317318-84-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 317318-84-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured Products
Product Name: GW0742 Request for quotationCAS: 317318-84-6
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: GW610742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GW0742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: GW0742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: GW0742 Visit Supplier Webpage Request for quotationCAS: 317318-84-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: GW0742 Visit Supplier Webpage Request for quotation
CAS: 317318-84-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 317318-84-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
GW0742
BOC-VAL-PRO-ARG-MCA
Benzofuran, 7-(chloromethyl)-
155486-33-2
2-Nathphalenyl disulfide
potassium benzenolate
3-(4-Chlorophenyl)-2-[[[phenylamino]thiocarbonylamino]iminomethyl]quinazolin-4(3H)-one
2307-11-1
55608-72-5
2,12-Diaza-3,7,11-triboratridecane, 3,7,11-tris(dimethylamino)-2,12-dimethyl- (7CI,8CI)
BOC-VAL-PRO-ARG-MCA
Benzofuran, 7-(chloromethyl)-
155486-33-2
2-Nathphalenyl disulfide
potassium benzenolate
3-(4-Chlorophenyl)-2-[[[phenylamino]thiocarbonylamino]iminomethyl]quinazolin-4(3H)-one
2307-11-1
55608-72-5
2,12-Diaza-3,7,11-triboratridecane, 3,7,11-tris(dimethylamino)-2,12-dimethyl- (7CI,8CI)