GSK525768A
GSK 525768A
CAS: 1260530-25-3
Molecular Formula: C22H22ClN5O2
GSK525768A - Names and Identifiers
GSK525768A - Physico-chemical Properties
| Molecular Formula | C22H22ClN5O2 |
| Molar Mass | 423.9 |
| Density | 1.35±0.1 g/cm3(Predicted) |
| Melting Point | 140-145℃ |
| Solubility | 10 mM in DMSO |
| pKa | 15.71±0.46(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | GSK 525768A has no activity towards BET. GSK 525768A (GSK525768A) is the (R)-enantiomer of GSK525762A. GSK525762A is shown to regulate levels of the high-density lipid protein apolipoprotein A1 (APOA1) in assays monitoring APOA1 release in liver cells, whereas the (R)-enantiomer (GSK 525768A) has no effect. GSK 525768A directly engages the protein module by forming hydrogen bonds with the conserved asparagine residue in a way that mimics the binding mode of acetylated lysine; this usually results in the binding of the inhibitor deeper within the acetylated lysine binding site but without displacing the conserved water molecules that are present at the bottom of the acetyl-lysine binding cavity. |
GSK525768A - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.359 ml | 11.795 ml | 23.591 ml |
| 5 mM | 0.472 ml | 2.359 ml | 4.718 ml |
| 10 mM | 0.236 ml | 1.18 ml | 2.359 ml |
| 5 mM | 0.047 ml | 0.236 ml | 0.472 ml |
Last Update：2024-01-02 23:10:35
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Product Name: GSK 525768A Visit Supplier Webpage Request for quotationCAS: 1260530-25-3
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Product Name: GSK 525768A Visit Supplier Webpage Request for quotationCAS: 1260530-25-3
Tel: +86-400-900-4166
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Mobile: +86-18621343501
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Product Name: GSK 525768A Visit Supplier Webpage Request for quotationCAS: 1260530-25-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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Product Name: GSK 525768A Visit Supplier Webpage Request for quotation
CAS: 1260530-25-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1260530-25-3
Tel: 18301782025
Email: 3008007409@qq.com
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View History
GSK525768A
四氢茚
thyroidextract
2-METHYLTHIO-2-IMIDAZOLINE HYDROIODIDE
N-[(2R)-3-[[3-Fluoro-4-(4-Morpholinyl)phenyl]aMino]-2-hydroxypropyl]acetaMide
76135-04-1
METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE
Carbamic acid, [(1S)-1-(hydroxymethyl)-2-phenyl-2-propenyl]-, 1,1-dimethylethyl ester
4,6-DICHLORO-2-PHENYLPYRIMIDIN-5-AMINE
2-Propen-1-one, 1-(3,5-dibromo-4-hydroxyphenyl)-3-(3-nitrophenyl)-
四氢茚
thyroidextract
2-METHYLTHIO-2-IMIDAZOLINE HYDROIODIDE
N-[(2R)-3-[[3-Fluoro-4-(4-Morpholinyl)phenyl]aMino]-2-hydroxypropyl]acetaMide
76135-04-1
METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE
Carbamic acid, [(1S)-1-(hydroxymethyl)-2-phenyl-2-propenyl]-, 1,1-dimethylethyl ester
4,6-DICHLORO-2-PHENYLPYRIMIDIN-5-AMINE
2-Propen-1-one, 1-(3,5-dibromo-4-hydroxyphenyl)-3-(3-nitrophenyl)-