Name | GSK3987 |
Synonyms | GSK3987 GSK3987 1-benzyl-3-((4-methoxyphenyl)amino)-4-phenyl-1H-pyrrole-2,5-dione |
CAS | 264206-85-1 |
Molecular Formula | C24H20N2O3 |
Molar Mass | 384.43 |
Solubility | Soluble in DMSO |
Storage Condition | -20℃ |
Use | GSK3987 is a potent and specific liver X receptor (LXR) dual agonist of LXRalpha and LXRbeta. |
Reference Show more | 1: Ranganathan PV, Jayakumar C, Ramesh G. Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization. Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F948-57. doi: 10.1152/ajprenal.00580.2012. Epub 2013 Feb 13. PubMed PMID: 23408164; PubMed Central PMCID: PMC3625850. 2: Lin HR. Paeoniflorin acts as a liver X receptor agonist. J Asian Nat Prod Res. 2013;15(1):35-45. doi: 10.1080/10286020.2012.742510. Epub 2013 Jan 3. PubMed PMID: 23281636. 3: Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure. J Med Chem. 2005 Aug 25;48(17):5419-22. PubMed PMID: 16107141. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.601 ml | 13.006 ml | 26.012 ml |
5 mM | 0.52 ml | 2.601 ml | 5.202 ml |
10 mM | 0.26 ml | 1.301 ml | 2.601 ml |
5 mM | 0.052 ml | 0.26 ml | 0.52 ml |