Name | GPI-1485 |
Synonyms | GM1485 GPI-1485 GPI-1485 L L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)- (2S)-1-(3,3-Dimethyl-2-oxopentanoyl)-pyrrolidine-2-carboxylic acid (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID |
CAS | 186268-78-0 |
Molecular Formula | C12H19NO4 |
Molar Mass | 241.28 |
Appearance | Solid |
Storage Condition | 2-8°C,密封,干燥 |
biological activity | GPI-1485 (GM1485) is a kind of immunosuppressant, promote neurological function improvement and nerve regeneration after stroke. |
Cell Line: | Normal human dermal fibroblasts (NHDF) [1] |
Concentration: | 100 μM |
Incubation Time: | |
Result: | Induced cellular reprogramming and neural cell induction. Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats. |
Animal Model: | Adult male Wistar rats, weighing 250-300 g |
Dosage: | 5 mg/kg |
Administration: | Intraperitoneal injection; daily; for a total of 42 days |