Fmoc-R-3-Amino-3-(4-chloro-phenyl)-propionic acid is an organic compound with the following properties:
-Appearance: White or off-white solid
-Solubility: Insoluble in water, soluble in some organic solvents such as dimethyl sulfoxide (DMSO)
Fmoc-R-3-Amino-3-(4-chloro-phenyl)-propionic acid is mainly used for the synthesis of peptide compounds in organic synthesis and deprotection reactions in polypeptide synthesis. It is a common intermediate of Fmoc protected amino acids and is often used as a starting material in peptide synthesis.
The method of preparing Fmoc-R-3-Amino-3-(4-chloro-phenyl)-propionic acid can be carried out by the following steps:
1. In an appropriate solvent, malonic acid and 4-chloroaniline are subjected to a condensation reaction by heating to obtain a propionamide precursor compound.
2. An N-carbonyl imine compound (e. g., Fmoc-OSu) is added as a protecting group to carry out an acylation reaction.
3. Using basic conditions, the protecting group (Fmoc) is removed to give Fmoc-R-3-Amino-3-(4-chloro-phenyl)-propionic acid.
When using, you need to pay attention to the following safety information:
- Fmoc-R-3-Amino-3-(4-chroo-phenyl)-propionic acid should be stored in a dry, well-ventilated place, away from ignition and flammable materials.
-Avoid contact with skin, eyes and respiratory tract during operation. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
-Wear appropriate protective gloves, glasses and masks during operation.
-When disposing of waste, it should be disposed of correctly in accordance with local regulations.