Fmoc-(R)-3-Amino-4-(4-bromo-phenyl)-butyric acid is an organic compound, which belongs to one of the commonly used protecting groups for synthetic peptides. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: White crystalline or powdery substance.
-Molecular formula: C? H? BrNO.
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide, dimethylformamide, etc.
-Melting point: approximately 110°C.
Use:
- Fmoc-(R)-3-Amino-4-(4-bromo-phenyl)-butyric acid is mainly used as a protecting group for synthetic peptides. It can introduce the Fmoc protecting group to the amino acid in the peptide chain by reacting with the amine group of the amino acid to protect the reactivity and selectivity of the amino acid during the synthesis.
-In solid phase synthesis, Fmoc-(R)-3-Amino-4-(4-bromo-phenyl)-butyric acid is commonly used to protect the C- terminus of synthetic peptides.
Preparation Method:
The preparation of - Fmoc-(R)-3-Amino-4-(4-bromo-phenyl)-butyric acid generally includes the following steps:
1. First, 3-amino -4-(4-bromophenyl) butanoic acid is reacted with Fmoc-Cl (dimethylformamide fluoroformate) to obtain the product.
2. Then purified by crystallization, the pure Fmoc-(R)-3-Amino-4-(4-bromo-phenyl)-butyric acid product can be obtained.
Safety Information:
- Fmoc-(R)-3-Amino-4-(4-bromo-phenyl)-butyric acid is a chemical and needs to be handled in accordance with relevant safety practices.
-Avoid inhaling its dust or solution and avoid contact with skin and eyes.
-Store and dispose of the compound appropriately to avoid contact with combustibles and oxidants.
-Wear appropriate personal protective equipment such as gloves, glasses and protective clothing when using or handling.