Fmoc-(R)-3-Amino-4-(3-thienyl)-butyric acid is an organic compound with the following properties:
1. properties: Fmoc-(R)-3-Amino-4-(3-thienyl)-butyric acid is a solid, the common form is white crystal. It is insoluble in water at normal temperature, but soluble in organic solvents such as dimethyl sulfoxide (DMSO) and methylene chloride.
2. application: Fmoc-(R)-3-Amino-4-(3-thienyl)-butyric acid is commonly used in solid phase synthesis as a protecting group for peptides and proteins. It can be coupled to other amino acids or peptide segments through solid phase synthesis reactions to construct polypeptides with specific sequences.
3. Preparation method: The synthesis of Fmoc-(R)-3-Amino-4-(3-thienyl)-butyric acid is usually completed by multi-step reaction. First, thiophene is activated by chloric acid and then esterified with (3R)-amino-4-hydroxybutyric acid to produce the target product. Finally, an Fmoc protecting group is introduced at the amino terminus to protect the reactivity of the amino acid.
4. safety information: Fmoc-(R)-3-Amino-4-(3-thienyl)-butyric acid specific safety information needs to be viewed according to the specific material safety data sheet (MSDS). Generally speaking, as a chemical, it may have an irritating effect on the skin and eyes, and care should be taken to avoid contact. When in use, wear appropriate personal protective equipment such as lab gloves and safety glasses. Also, it should be operated in a well-ventilated place. Appropriate laboratory practices and safe operating procedures should be followed during handling and storage.