FLLL-31
Tetramethylcurcumin
CAS: 52328-97-9
Molecular Formula: C25H28O6
FLLL-31 - Names and Identifiers
FLLL-31 - Physico-chemical Properties
| Molecular Formula | C25H28O6 |
| Molar Mass | 424.49 |
| Density | 1.140±0.06 g/cm3(Predicted) |
| Boling Point | 594.5±50.0 °C(Predicted) |
| Solubility | Insuluble (5.1E-3 g/L) (25 °C) |
| Appearance | Yellow powder |
| Color | yellow |
| Storage Condition | 2-8°C |
| MDL | MFCD19443859 |
| In vitro study | Tetramethylcurcumin (FLLL31; 2.5 and 5 µM;for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines. |
FLLL-31 - Risk and Safety
| WGK Germany | 3 |
FLLL-31 - Reference
| Reference Show more | 1. [IF=7.514] Shuailong Jia et al."Discrimination of turmeric from different origins in China by MRM-based curcuminoid profiling and multivariate analysis."Food Chem. 2021 Feb;338:127794 2. [IF=4.946] Lai Yanni et al."3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase."Arch Pharm Res. 2020 May;43(5):489-502 |
FLLL-31 - Reference Information
| biological activity | tetramethlencumin (FLLL31) is derived from curcumin, phosphorylation of STAT3 is specifically inhibited by selective binding of Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anti-cancer effects. |
Last Update：2024-04-09 20:49:11
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View History
FLLL-31
羧乙基三苯基溴化膦
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexane-1-one
3,9-DIAMINO-ACRIDINE
Tris (4-Isocyanatophenyl) Thiophosphate
(4-bromo-1-methyl-pyrazol-3-yl)methanol
2,4-DICHLOROPHENYL 3-(METHOXYIMINO)PROPANOATE
1H-Pyrazolo[3,4-b]pyridine, 3-(1-methylethyl)-5-nitro-
羧乙基三苯基溴化膦
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexane-1-one
3,9-DIAMINO-ACRIDINE
Tris (4-Isocyanatophenyl) Thiophosphate
(4-bromo-1-methyl-pyrazol-3-yl)methanol
2,4-DICHLOROPHENYL 3-(METHOXYIMINO)PROPANOATE
1H-Pyrazolo[3,4-b]pyridine, 3-(1-methylethyl)-5-nitro-