Doxazosin
Doxazosin
CAS: 74191-85-8
Molecular Formula: C23H25N5O5
Doxazosin - Names and Identifiers
| Name | Doxazosin |
| Synonyms | UK 33274 DOXAZOSIN Doxazosin UK 33,274 DOXAZOSIN(SUBJECTTOPATENTFREE) Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]- [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone [4-(4-amino-6,7-dimethoxy-quinazolin-2- yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone [4-(4-Amino-6,7-dimethoxy-quinazolin-2- yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone |
| CAS | 74191-85-8 |
| EINECS | 244-065-5 |
| InChI | InChI=1/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4) |
Doxazosin - Physico-chemical Properties
| Molecular Formula | C23H25N5O5 |
| Molar Mass | 451.48 |
| Density | 1.371±0.06 g/cm3(Predicted) |
| Melting Point | 289-290°C |
| Boling Point | 718.0±70.0 °C(Predicted) |
| Flash Point | 388°C |
| Vapor Presure | 1.83E-20mmHg at 25°C |
| pKa | 6.52±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Doxazosin hydrochloride: C23H25N5O5? HCI. Crystalline, melting point 289-290 °c. Doxazosin Mesylate: C23H25N5O5? CH403S. [77883-43-3]. White or yellowish white crystalline powder, odorless. Soluble in dimethyl sulfoxide, more difficult to dissolve in glacial acetic acid, difficult to dissolve in methanol, ethanol or water, very difficult to dissolve in chloroform, a few do not dissolve in ether. Melting point 270~275 °c (decomposition). |
| Use | Its activity is similar to that of prazosin, but stronger. Apply to high blood pressure, especially high blood pressure caused by Brown cell tumor. |
Doxazosin - Nature
Open Data Verified Data
Crystal, melting point 289~290 °c.
Last Update：2024-01-02 23:10:35
Doxazosin - Preparation Method
Open Data Verified Data
4-amino -2-oxygen -6,7-= methoxy imidazoline and 2-(1-piperazinyl)-1,4-benzobis n-oxane reaction, doxazosin was obtained.
Last Update：2022-01-01 09:10:29
Doxazosin - Use
Open Data Verified Data
antihypertensive efficacy and safety were comparable to enalapril, prazosin, or Atenolol. Apply to high blood pressure, especially high blood pressure caused by Brown cell tumor. For primary mild to moderate hypertension and hypertension associated with benign prostatic hypertrophy. Doxazosin can be used in combination with a diuretic, a p-blocker, a calcium antagonist, or an angiotensin-converting enzyme inhibitor in patients whose blood pressure is difficult to control with a single drug.
Last Update：2022-01-01 09:10:29
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View History
Doxazosin
Anthraquinone-1,4-diyl)diether
1379324-59-0
10088-50-3
N-(4-fluorophenyl)-4-[(2-hydroxybenzylidene)amino]benzenesulfonamide
1001500-40-8
2-chloro-6-(pyrrolidin-1-yl)benzaldehyde
Benzenepropanal, 4-iodo-
2459302-78-2
1H-Indene-1,3(2H)-dione, 2,2-diethyl-4,6-dimethyl-
Anthraquinone-1,4-diyl)diether
1379324-59-0
10088-50-3
N-(4-fluorophenyl)-4-[(2-hydroxybenzylidene)amino]benzenesulfonamide
1001500-40-8
2-chloro-6-(pyrrolidin-1-yl)benzaldehyde
Benzenepropanal, 4-iodo-
2459302-78-2
1H-Indene-1,3(2H)-dione, 2,2-diethyl-4,6-dimethyl-