Disulfiram-d20 - Names and Identifiers
Disulfiram-d20 - Physico-chemical Properties
Molecular Formula | C10H20N2S4
|
Molar Mass | 296.52 |
Melting Point | 51-58°C |
Storage Condition | Refrigerator |
Disulfiram-d20 - Reference
Reference Show more | 1. Feng Bing-yu, Zhu Yuan-gang, Wei Liang, etc. Inhibitory effect of artemisinin-β-Cyclodextrin Inclusion Complex combined with disulfiram on liver metastasis of colorectal cancer in vivo [J]. Specialty research, 2020, 042(001):6-10. |
Disulfiram-d20 - Introduction
Disulfiram-d20 is a heavy Proton substitute, its chemical formula is C10H20N2S2O-d20. It is a double proton substitute for aniline dithionyl compounds, similar to the common Disulfiram, but substituting two hydrogen atoms for heavy deuterium atoms.
The main use of Disulfiram-d20 is to study and analyze the metabolism and efficacy of the drug diulfiram, especially for pharmacokinetic studies through nuclear magnetic resonance technology (NMR). It can be used to determine the distribution, metabolism and excretion pathways of Disulfiram in the body, as well as to evaluate drug interactions with other substances.
The preparation method of Disulfiram-d20 is similar to that of Disulfiram, which is obtained by reacting aniline with dithionyl chloride and then metabolizing with heavy water (sodium deuterium oxide). This process ensures the production of Disulfiram-d20, I .e., a D2 substitute containing the heavy dehydrosulfates.
Regarding safety information, Disulfiram-d20 is a relatively safe compound when used correctly. However, it is still a toxic compound and requires safe laboratory practices. Appropriate personal protective measures such as gloves, lab clothes and goggles are required when handling and using Disulfiram-d20. In addition, should avoid inhalation of its dust or vapor, avoid skin contact or ingestion. In case of accidental exposure or inhalation, seek medical help immediately.
Last Update:2024-04-09 20:52:54