Molecular Formula | C25H25F3N4O6 |
Molar Mass | 534.48 |
Density | 1.45 |
Melting Point | 195-196℃ |
Boling Point | 653.7±65.0 °C(Predicted) |
Solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly, Sonicated) |
Appearance | Solid |
Color | Off-White to Light Yellow |
pKa | 3.99±0.20(Predicted) |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Hygroscopic |
Physical and Chemical Properties | The biological activity of Delamanid (OPC-67683) is a new type of anti-tuberculosis drug, which has good intracellular bactericidal activity and high accumulation rate in cells. |
In vitro study | Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex. Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis. Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration. |
In vivo study | Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.871 ml | 9.355 ml | 18.71 ml |
5 mM | 0.374 ml | 1.871 ml | 3.742 ml |
10 mM | 0.187 ml | 0.935 ml | 1.871 ml |
5 mM | 0.037 ml | 0.187 ml | 0.374 ml |