DOXAPRAMHYDROCHLORIDE,ANHYDROUS
Doxapram Hydrochloride
CAS: 113-07-5
Molecular Formula: C24H31ClN2O2
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Names and Identifiers
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Physico-chemical Properties
| Molecular Formula | C24H31ClN2O2 |
| Molar Mass | 414.96814 |
| Boling Point | 536.4°C at 760 mmHg |
| Flash Point | 278.2°C |
| Vapor Presure | 1.4E-11mmHg at 25°C |
| Storage Condition | Sealed in dry,Room Temperature |
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Risk and Safety
| UN IDs | 3249 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Standard
Authoritative Data Verified Data
This product is (±) 1-ethyl -3, 3-monophenyl-4-(2-morenyl ethyl)-2-pyrrolidone hydrochloride monohydrate. The content of C24H30N202 • HC1 shall be between 98.0% and 100.5% based on the dry product.
Last Update：2024-01-02 23:10:35
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is slightly soluble in water, chloroform or ethanol, and insoluble in ether.
melting point
The melting point of this product (General 0612) is 217~221°C.
Last Update：2022-01-01 15:03:44
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Differential diagnosis
Authoritative Data Verified Data
- take this product, add water to dissolve and make a solution containing about 0.4mg per lml, according to UV-visible spectrophotometry (General rule 0401), at 252nm, there is a maximum absorption at the wavelength of 258nm and 264nm, and a minimum absorption at the wavelength of 244nm, 254nm and 262nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 643).
- This product is chloride identification reaction (General 0301).
Last Update：2022-01-01 15:03:45
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Exam
Authoritative Data Verified Data
acidity
take 0.50g of this product, add 50ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 3.5~5.0.
clarity and color of solution
take this product l.Og, add water 50ml dissolved, the solution should be clear and colorless.
Related substances
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 1 mg per 1 ml, as a test solution; Take an appropriate amount of precision, A solution containing about 2ug per 1 ml was prepared as a control solution by quantitative dilution with water. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with a Eighteen alkyl silane was used as a filler (end-capped column). Olmol/L sodium acetate solution (adjusted to pH 4.5 with glacial acetic acid)-acetonitrile (70:30) as mobile phase, the detection wavelength was 214nm. l0ul of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 4 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2%), and the sum of each impurity peak area shall not be greater than 5 times the area of the main peak of the control solution (1.0%).
loss on drying
take this product, dry at 105°C for 2 hours, loss weight should be 3.0% ~ 4.5% (General 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.3%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
arsenic salt
take l.Og of this product, add 5ml of hydrochloric acid and 23ml of water to dissolve, check according to law (General rule 0822 first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 15:03:45
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Content determination
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, add glacial acetic acid 20ml and acetic anhydride 20ml dissolved, according to the potential titration method (General rule 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 41.50mg of C24H30N2O2. HCI.
Last Update：2022-01-01 15:03:46
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Category
Authoritative Data Verified Data
Central stimulant.
Last Update：2022-01-01 15:03:46
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:03:46
DOXAPRAMHYDROCHLORIDE,ANHYDROUS - Doxapram Hydrochloride Injection
Authoritative Data Verified Data
This product is a sterilized aqueous solution of doxapram hydrochloride. Containing doxapram hydrochloride (C24H30N2O2 • HCI • H20) shall be between 90.0% and 110.0% of label load.
trait
This product is colorless and clear liquid.
identification
- take an appropriate amount of this product and dilute it with water to make it contain about 0.1 mg of the solution, as the test solution; Take an appropriate amount of doxapram hydrochloride control, add water to dissolve and dilute to make about 0 per 1 ml. 1 mg solution, as a control solution. According to the chromatographic conditions under the items of related substances, each lol of the test solution and the reference solution is injected into the liquid chromatograph respectively, and the chromatograms are recorded, the retention time of the main peak in the chromatogram of the test solution should be consistent with the retention time of the main peak of the control solution.
- take the test solution under the content determination item, according to ultraviolet-visible spectrophotometry (General 0401), there is maximum absorption at the wavelength of 252nm, 258nm and 264nm, there is minimal absorption at wavelengths of 244Nm, 254nm and 262NM.
- This product chloride identification (1) of the reaction (General 0301).
examination
- the pH value should be 3.5 to 5.5 (General 0631).
- appropriate amount of related substances of this product is diluted with water to prepare a solution containing 1 mg doxapram hydrochloride per 1 ml as a test solution, the determination was carried out according to the method for related substances of doxapram hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2%), the sum of each impurity peak area shall not be greater than 5 times (1.0%) of the main peak area of the control solution.
- bacterial endotoxin take this product, according to the law inspection (General 1143), each 1 mg doxapram hydrochloride containing endotoxin amount should be less than 1.0EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take 5ml of this product with precision, put it in a 250ml measuring flask, dilute it to the scale with water, shake it well, and use it as a test solution, according to ultraviolet-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 258mn; Take appropriate amount of doxapram hydrochloride reference substance, weigh it precisely, dissolve it with water and dilute it quantitatively to make a solution containing about 0.4mg per 1 ml, measure and calculate with the same method, that's right.
category
Same as doxapram hydrochloride.
specification
5ml:lOOmg
storage
light shielding, closed storage.
Last Update：2022-01-01 15:03:47
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View History
DOXAPRAMHYDROCHLORIDE,ANHYDROUS
4H-1-Benzopyran-4-one, 3,5,7-tris(1-methylethoxy)-2-[4-(1-methylethoxy)phenyl]-
[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-triphenylphosphonium bromide
3-Hydroxy-bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester
(4-甲基萘-1-基)甲醇
ATRIOPEPTIN III (RAT)
2-acetylthiomethyl-3-(4-methylbenzoyl)propionic acid
苯基二甲基乙氧基硅烷
2-甲基-2-吗啉-4-基丙-1-胺碳酸酯
三(4-乙烯基苯基)膦
4H-1-Benzopyran-4-one, 3,5,7-tris(1-methylethoxy)-2-[4-(1-methylethoxy)phenyl]-
[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-triphenylphosphonium bromide
3-Hydroxy-bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester
(4-甲基萘-1-基)甲醇
ATRIOPEPTIN III (RAT)
2-acetylthiomethyl-3-(4-methylbenzoyl)propionic acid
苯基二甲基乙氧基硅烷
2-甲基-2-吗啉-4-基丙-1-胺碳酸酯
三(4-乙烯基苯基)膦