Name | DJ001 |
Synonyms | DJ001 |
CAS | 2161305-12-8 |
Molecular Formula | C15H12N2O3 |
Molar Mass | 268.27 |
Solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming) |
Appearance | solid |
Color | Yellow |
Storage Condition | -20°C |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
biological activity | DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-Sigma (ptpσ) inhibitor, IC50 1.43 μm. DJ001 had no inhibitory activity against other phosphatases and only moderate inhibitory activity against protein phosphatase 5. DJ001 promotes hematopoietic stem cell regeneration. |
Target | IC50: 1.43 μm |
Cell Line: | BM KSL cells |
Concentration: | 5 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL |
Incubation Time: | 3 days or 7 days |
Result: | Increased the percentages and numbers of BM KSL cells. Also significantly increased the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells. Significantly decreased the percentage of apoptotic BM KSL cells in C57BL/6 mice at 24 h following 500 cGy TBI. |
Animal Model: | Female C57BL/6 mice (8-10-week-old) irradiated with total body irradiation (TBI) |
Dosage: | 5 mg/kg |
Administration: | Subcutaneous injection; for 24 hours |