DC_05
DC-05
CAS: 890643-16-0
Molecular Formula: C25H25N3O
DC_05 - Names and Identifiers
| Name | DC-05 |
| Synonyms | DC_05 DC-05 DC_05(DC-05) 9H-Carbazole-9-ethanol, α-[[[2-(1H-indol-3-yl)ethyl]amino]methyl]- |
| CAS | 890643-16-0 |
DC_05 - Physico-chemical Properties
| Molecular Formula | C25H25N3O |
| Molar Mass | 383.5 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Boling Point | 667.5±55.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 13.72±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC 50 and a K d of 10.3 μM and 1.09 μM, respectively. DC-05 shows less potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC 50 : >200, >200, >150, >150, >150, >150, 37.1 μM). DC-05 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. |
DC_05 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.608 ml | 13.038 ml | 26.077 ml |
| 5 mM | 0.522 ml | 2.608 ml | 5.215 ml |
| 10 mM | 0.261 ml | 1.304 ml | 2.608 ml |
| 5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Last Update：2024-01-02 23:10:35
DC_05 - Reference Information
| biological activity | DC-05 is a DNMT1 inhibitor with IC50 and Kd values of 10.3 μm and 1.09 μm, respectively. |
Last Update：2024-04-09 21:04:16
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Product Name: DC-05 Visit Supplier Webpage Request for quotationCAS: 890643-16-0
Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
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Mobile: +86-18821248368
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Product Name: DC-05 Visit Supplier Webpage Request for quotation
CAS: 890643-16-0
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CAS: 890643-16-0
Tel: 18301782025
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View History
DC_05
4-(2-CHLORO-5-(TRIFLUOROMETHYL)PHENYLAZO)-3-HYDROXY-2-NAPHTHOIC ACID
2-[[(3-carboxyphenyl)amino]carbonyl]-4-mercapto-1-pyrrolidinecarboxylic acid (2s-cis)-1-[(4-nitrophenyl)methyl] ester
1(2H)-Chrysenone, 3,4,4a,4b,5,6,10b,11,12,12a-decahydro-8-methoxy-, [4aS-(4aα,4bβ,10bα,12aβ)]- (9CI)
氟米龙杂质4
别藻蓝蛋白(APC)
2-Methyl-1-cyclohexanone
5-AMINOMETHYL-PYRIMIDINE-2,4-DIAMINE
1-(2-chloro-4-methoxy-5-methylphenyl)-2-thiocyanatopropan-1-one
1-(2-Cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol
4-(2-CHLORO-5-(TRIFLUOROMETHYL)PHENYLAZO)-3-HYDROXY-2-NAPHTHOIC ACID
2-[[(3-carboxyphenyl)amino]carbonyl]-4-mercapto-1-pyrrolidinecarboxylic acid (2s-cis)-1-[(4-nitrophenyl)methyl] ester
1(2H)-Chrysenone, 3,4,4a,4b,5,6,10b,11,12,12a-decahydro-8-methoxy-, [4aS-(4aα,4bβ,10bα,12aβ)]- (9CI)
氟米龙杂质4
别藻蓝蛋白(APC)
2-Methyl-1-cyclohexanone
5-AMINOMETHYL-PYRIMIDINE-2,4-DIAMINE
1-(2-chloro-4-methoxy-5-methylphenyl)-2-thiocyanatopropan-1-one
1-(2-Cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol