| Name | COPPER (II) GLUCONATE |
| Synonyms | copper D-gluconate GLUCONICACIDCOPPER COPPER (II) GLUCONATE D-Gluconicacid,coppersalt COPPER (II) GLUCONATE, MIN. 98 |
| CAS | 13005-35-1 |
| EINECS | 235-844-0 |
| Molecular Formula | C12H22CuO14 |
| Molar Mass | 453.84068 |
| Melting Point | 156°C |
| Appearance | Form Powde, color blue |
| Physical and Chemical Properties | Chemical properties light blue crystal or powder, odorless. Melting point 155~157 ℃. Easily soluble in water, hardly soluble in ethanol. Mouth LD500.419g/kg in mice (Harbin Medical University). |
| Use | Use of copper gluconate is a good Nutrition Fortifier, China's provisions can be used for infant formula food, the use of 7.5~10mg/kg (copper, the same below); in dairy products is 5.7~7.5mg/kg. |
| Raw Materials | FUMING SULFURIC ACID D(+)-Glucose Barium hydroxide Copper(II) sulfate pentahydrate Calcium gluconate AMBERLITE(R) IRC-50 Ozone Gluconic acid Copper(II) gluconate C. I. Pigment Blue 30 (77420) |
fermentation method
Using glucose as raw material, it is fermented and oxidized by black mold to produce gluconic acid, and then reacts with copper carbonate (or basic copper carbonate) to produce copper gluconate. This method has huge production equipment, high concentration energy consumption, and difficult purification and crystallization.
Direct method
Copper gluconate is produced by the direct reaction of calcium gluconate and copper sulfate. The process is simple, but the residual calcium sulfate is difficult to remove.
Chemical oxidation
Glucose is used as raw material, oxidized to gluconic acid with ozone, concentrated under reduced pressure, dehydrated to obtain gluconate lactone, and then reacted with copper carbonate to form copper gluconate.
Acidification
Add 1.2mol of calcium gluconate into equimolar sulfuric acid solution, react at 60~90 ℃ for 1~2h, and filter out the precipitate of calcium sulfate while hot to obtain colorless or yellowish gluconic acid solution (relative density 1.12~1.16). 4g of barium hydroxide aqueous solution and 1.5g of oxalic acid aqueous solution were added dropwise to the above gluconic acid solution, and the reaction was stirred for 15min to remove the residual Ca2 + and S02-. The purified liquid passes through the anion and cation exchange resin to obtain a colorless and transparent gluconic acid solution.
In addition, 1mol of crystalline copper sulfate solution and 2mol of sodium hydroxide solution are mixed, reacted at 40~60 ℃ for 0.5~1h, filtered, and the filter cake is washed with water to obtain black copper oxide crystals. The copper oxide crystals were added to the gluconic acid solution in batches, reacted for lh, filtered to remove the unreactants, cooled to stand for 3~5h, and then crystallized. Add appropriate amount of 95% ethanol, stir into paste and filter, and the filter cake is vacuum dried at 50 ℃ to obtain the finished product with a yield of 90%-92.5%.