Cyclo(RGDyK)
Cyclic Arg-Gly-Asp-D-Tyr-Lys
CAS: 250612-42-1
Molecular Formula: C29H42F3N9O10
Cyclo(RGDyK) - Names and Identifiers
Cyclo(RGDyK) - Physico-chemical Properties
| Molecular Formula | C29H42F3N9O10 |
| Molar Mass | 733.7 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | Cyclo(RGDyK) exhibits higher affinity and selectivity for αVβ3 than for αVβ5 and αiibβ3. Compared to the Cyclo(RGDyK)-free micelles (NPM), The Cyclo(RGDyK)-bound micelles (TPM) are mediated by integrin-mediated endocytosis, promotes cell-specific uptake of DiI by B16-F10 cells and HUVECs. |
| In vivo study | In apoE −/− mice, Cyclo(RGDyK) (1 nmol, I. v.) inhibited the increased expression of αVβ3 integrin in the intima of the left stenotic carotid artery. |
Cyclo(RGDyK) - Reference Information
| biological activity | Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM. |
| Target | TargetValue αVβ3 integrin 20 nM |
| Target | Value |
| αVβ3 integrin | 20 nM |
| In vitro studies | Cyclo(RGDyK) exhibited higher affinity and selectivity for αVβ3 than for αVβ5 and αiibβ3. Compared to the Cyclo(RGDyK)-free micelles (NPM), The Cyclo(RGDyK)-bound micelles (TPM) are mediated by integrin-mediated endocytosis, promotes cell-specific uptake of DiI by B16-F10 cells and HUVECs. |
| in vivo studies | in apoE −/− mice, Cyclo(RGDyK) (1 nmol, I. v.) inhibits the increase of αVβ3 integrin expression in the intima of the left-sided stenotic carotid artery. |
Last Update：2024-04-09 21:01:54
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