Name | Corilagin |
Synonyms | Corilagin CORILAGIN CORILAGIN(SH) 1-O-Galloyl-3,6-hexahydroxydiphenol-b-D-Glucopyranose 1-O-GALLOYL-3,6-HEXAHYDROXYDIPHENOYL-BETA-D-GLUCOPYRANOSE Galloyl 3-O,6-O-[(4,4',5,5',6,6'-hexahydroxy-1,1'-biphenyl-2,2'-diyl)biscarbonyl]-β-D-glucopyranoside 1-O-Galloyl-3-O,6-O-[2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbiscarbonyl]-β-D-glucopyranose B-D-GLUCOPYRANOSE, CYCLIC 3,6-(4,4',5,5',6,6'-HEXAHYDROXY[1,1'-BIPHENYL]-2,2'-DICARBOXYLATE)1-(3,4,5-TRIHYDROXYBENZOATE), (R)- beta-D-Glucopyranose, cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy(1,1'-biphenyl)-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), (R)- 1,2,3,11,16,17,18,19-octahydroxy-5,14-dioxo-5,7,8,11,12,14-hexahydro-10H-8,12-methanodibenzo[j,l][1,4,8]trioxacyclotetradecin-10-yl 3,4,5-trihydroxybenzoate (8R,10S,11R,12S,19R)-1,2,3,11,16,17,18,19-octahydroxy-5,14-dioxo-5,7,8,11,12,14-hexahydro-10H-8,12-methanodibenzo[j,l][1,4,8]trioxacyclotetradecin-10-yl 3,4,5-trihydroxybenzoate |
CAS | 23094-69-1 |
InChI | InChI=1/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2 |
InChIKey | TUSDEZXZIZRFGC-XIGLUPEJSA-N |
Molecular Formula | C27H22O18 |
Molar Mass | 634.46 |
Density | 2.11±0.1 g/cm3(Predicted) |
Melting Point | >200°C dec |
Boling Point | 1280.8±65.0 °C(Predicted) |
Specific Rotation(α) | -8.70°(C=1.0,acetone),-224°(c=0.8,Ethanol) |
Flash Point | 418.7°C |
Solubility | Easily soluble in ethanol, methanol, acetone, slightly soluble in water. |
Vapor Presure | 0mmHg at 25°C |
Appearance | White fine needle crystals (crystallized in methanol-water (1:1) solvent) |
Color | Off-White |
pKa | 7.53±0.70(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Stability | Hygroscopic |
Sensitive | Easily absorbing moisture |
Refractive Index | 1.88 |
MDL | MFCD00238565 |
Physical and Chemical Properties | Light yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Phyllanthus, geranium, citrus grass, White three grass. |
WGK Germany | 3 |
Reference Show more | 1. Cao Bo Yin Haibo Jia Xiaoqing et al. Simultaneous Determination of 7 Components in 3 Geranium Species by HPLC [J]. 2016 38(6):1338-1342. 2. Liao Bin, Li Shanshan, Liang Zihao et al. Effect of Light Quality on Corilagin Content in Embryogenic Callus of Longan [J]. Subtropical Agricultural Research 2018 014(002):128-133. 3. Liao Bin, xu Xiaoping, Li Shanshan, et al. Effects of phenylalanine and methyl jasmonate on the accumulation of kelilagin in longan embryogenic suspension cells. Journal of Application and Environmental Biology. 4. Sun Hanzheng, Sun Peidong. Study on extraction, separation and antioxidant properties of longan nuclear polyphenols [J]. Food and Fermentation Industry, 2019(9). 5. Zhang Yuanyuan, Gan Kang, Gao Shuting, etc. determination of 7 tannins in Tibetan medicine chebula from different origins by high performance liquid chromatography [J]. Chinese journal of pharmacy, 2017(12):1073-1082. 6. Liu Xiaoli, Yang Bingxin, Chen Liuqing, et al. HPLC determination of 3 polyphenols and antioxidant activities in Phyllanthus emblica tea [J]. Food Industry Science and Technology 2020(13). 7. Wu Lingfang, liang Wenyi, Zhang Lanzhen. Study on Determination of Main Components of Tibetan Medicine Phyllanthus emblica [J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2020,22(08):2857-2863. 8. [IF = 7.514] Junwei Cao et al."Number of galloyl moiety and intramolecular bonds in galloyl-based polyphenols effect their interaction with alpha-glucosidase." Food Chem. 2022 Jan;367:129846 9. [IF = 5.396] Junwei Cao et al."Number of galloyl moieties and molecular flexibility are both important in alpha-amylase inhibition by galloyl-based polyphenols." Food Funct. 2020 May;11(5):3838-3850 10. [IF = 5.037] Yun Li et al."Corilagin alleviates hypertrophic scars via inhibiting the transforming growth factor (TGF)-β/Smad signal pathway." Life Sci. 2021 Jul;277:119483 11. [IF = 3.72] Li Lu-Jun et al."Corilagin Interferes With Toll-Like Receptor 3-Mediated Immune Response in Herpes Simplex Encephalitis." Front Mol Neurosci. 2019 Apr;12:83 12. [IF = 3.703] Rakariyatham Kanyasiri et al."Improvement of Phenolic Contents and Antioxidant Activities of Longan (Dimocarpus longan) Peel Extracts by Enzymatic Treatment." Waste Biomass Valori. 2020 Aug;11(8):3987-4002 13. [IF = 2.478] Kun Li et al."Composition, Antivirulence Activity, and Active Property Distribution of the Fruit of Terminalia chebula Retz." J Food Sci. 2019 Jul;84(7):1721-1729 14. [IF = 2.1] Jilan Liu et al."Corilagin induces apoptosis and autophagy in NRF2-addicted U251 glioma cell line." Mol Med Rep.2021 May;23(5):1-10 15. [IF = 6.576] Guowei Man et al."Profiling Phenolic Composition in Pomegranate Peel From Nine Selected Cultivars Using UHPLC-QTOF-MS and UPLC-QQQ-MS." Front Nutr.2021; 8: 807447 16. [IF = 2.952] Shu Jia et al."Corilagin induces apoptosis and inhibits autophagy of HL -60 cells by regulating miR -451/HMGB1 axis." Mol Med Rep. 2022 Jan;25(1):1-9 |
Introduction | Curilagin (corilagin,Cor),1-acyl -3, 6-hexahydroxybiphenyl diformyl glucose, also known as Kezi Tanning, Helijing, Tanning (material) Yunshi essence, is a natural plant polyphenol tannic acid compound, it is an effective ingredient in plants such as Phyllanthus, Geranium, Mandarin Grass, and White Three Grass. It also exists in plants with antioxidant and anti-aging effects such as Phyllanthus emblica, longan, and olive. |
application | corilagin has a wide range of biological activities such as anti-tumor, anti-oxidation, anti-atherosclerosis, anti-fibrinolysis, lowering blood pressure, inhibiting virus, antibacterial, anti-inflammatory, etc. |
effect | corilagin's protective effect on cardiovascular system mainly focuses on its antihypertensive, anticoagulant and defibrillating effects, inhibiting thrombosis, preventing ischemia-reperfusion injury, inhibiting oxidation of low density lipoprotein, etc. |
Biological activity | Corilagin (Corilagin) is a tannic acid that can be separated from Caesalpinia coriaria (Jacq.). Corilagin inhibits the activity of RNA tumor virus reverse transcriptase. Corilagin inhibit the growth of Staphylococcus aureus with MIC of 25 μg/mL. Corilagin has good anti-tumor activity against liver cancer and ovarian cancer, while its toxicity to normal cells and tissues is very low. |
use | corilagin is antibacterial and antihypertensive,. Anti-liver toxicity, inhibition of reverse transcriptase, inhibition of mutation, anti-virus, anti-tumor, anti-atherosclerosis, anti-oxidation, anti-fibrinolysis, lowering blood pressure. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: it has antibacterial effect, anti-hypertensive effect, anti-liver toxicity effect, inhibition of reverse transcriptase, anti-cancer, anti-virus and other pharmacological effects. |