Name | diamfenetide |
Synonyms | Coriban coryphamin acemidophene diamfenetide .beta.,.beta.'-Oxybis[p-acetophenetidide] n,n'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bisacetamide n,n'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-acetamid N,N'-[Oxybis(2,1-ethanediy-loxy-4,1-phenylene)]bisacetamide Acetamide, N,N'-[oxybis(2,1-ethanediyloxy-4,1-phenylene)]bis- |
CAS | 36141-82-9 |
EINECS | 252-886-5 |
Molecular Formula | C20H24N2O5 |
Molar Mass | 372.42 |
Physical and Chemical Properties | White or light yellow crystalline powder. Melting point 142 ℃. Slightly soluble in ethanol, insoluble in water. |
In vitro study | Diamfenetide (10-100μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica.Diamfenetide (100μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes. |
biological activity | Diamfenetide was used for in vitro studies of Fasciola hepatica infection. Diamfenetide causes irreversible paralysis of adult and juvenile Fasciola hepatica. |
Use | Anti-Fasciola hepatica larva disease. The larvae before 6 weeks of age effect is remarkable, worm reduction rate is almost 100, can be used for the treatment of cattle, sheep slice Fasciola larvae disease. The product has low toxicity. The LD50 of oral, subcutaneous and intraperitoneal administration was greater than 3000mg/kg in mice. Sheep were dosed at 400-1600mg/kg, and only a few animals died, depilated, and temporarily visually impaired. This product has no adverse effect on lactation, pregnancy and weak livestock, and has no effect on milk yield and milk quality. |
production method | β,β'-dichloroethyl ether was obtained from diethylene glycol catalyzed by pyridine and thionyl chloride, it is then obtained by condensation with acetaminophen. |