Name | Oxatomide |
Synonyms | tinset Dasten Cobiona Celtect Oxatomide oxatomida 1-[3-[4-(DIPHENYLMETHYL)-1-PIPERAZINYL]PROPYL]-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE |
CAS | 60607-34-3 |
EINECS | 262-320-9 |
Molecular Formula | C27H30N4O |
Molar Mass | 426.55 |
Density | 1.1239 (rough estimate) |
Melting Point | 153.60C |
Boling Point | 541.98°C (rough estimate) |
Solubility | DMSO: soluble |
Appearance | White solid. |
Color | white |
pKa | 12.20±0.30(Predicted) |
Storage Condition | Refrigerator |
Refractive Index | 1.6000 (estimate) |
Physical and Chemical Properties | The chemical properties are crystallized from aqueous ethanol with a melting point of 153.6 ℃. Acute toxic LD50 mice, rats, guinea pigs (mg/kg):27,30,23 intravenous injection. Acute toxicity LD50 guinea pigs, dogs, mice, male rats, female rats (mg/kg):320,>1280,>2560,>2560,1670 oral administration. |
Use | Use histamine H1 receptor antagonist. It is used to treat allergic rhinitis, conjunctivitis, urticaria, food allergy, skin itching and bronchial asthma in children. It has special effects on chronic urticaria. Antihistamines, antiasthmatic drugs. |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | DE2276000 |
Toxicity | LD50 in guinea pigs, mice, rats (mg/kg): 320, >2560, >2560 orally; 23, 27, 30 i.v. (Richards) |