Cefonicid
Cefonicid
CAS: 61270-58-4
Molecular Formula: C18H18N6O8S3
Cefonicid - Names and Identifiers
Cefonicid - Physico-chemical Properties
| Molecular Formula | C18H18N6O8S3 |
| Molar Mass | 542.57 |
| Density | 1.92±0.1 g/cm3(Predicted) |
| pKa | -1.23±0.50(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.852 |
| Physical and Chemical Properties | Soluble in ethyl acetate. |
Cefonicid - Nature
Open Data Verified Data
dissolved in ethyl acetate.
cefonicid sodium (ce-fonicid dexodiitun salt):CAS accession number [61270-78-8]Last Update：2024-01-02 23:10:35
Cefonicid - Quality standards-Chinese Pharmacopoeia 2005 edition
Open Data Verified Data
cefonicid sodium; Cefonicid containing not less than 832trg and not more than 970tig per 1mg calculated as anhydrous (Ci8 Hi8 N6 08 s3); the content of cefonicid per 1mg is not more than 0. 35 of the USP Endotoxin lpH value should be 3.5~6.5(1mg of the product dissolved in 20ml of water); Containing water should not be greater than so%.
Last Update：2022-01-01 08:52:27
Cefonicid - Preparation Method
Open Data Verified Data
potassium hydroxide and aminomethanesulfonic acid were dissolved in water and carbon disulfide was added. After stirring, ethanol was added, followed by methyl iodide. After completion of the reaction, a solid was obtained by cooling and filtration. The solid was extracted with hot methanol, and the extract was concentrated to obtain a potassium salt of methyl N-sulfomethyldithiocarbamate. The obtained potassium salt of methyl N-sulphomethyldithiocarbamate and sodium azide were dissolved in water and heated at 80 °c for 4.75 H. The reaction solution was passed through an ion exchange resin column and was developed with water until the pH of the effluent reached 3.5. The effluent was extracted with diethyl ether and concentrated to dryness to give 1 sulfomethyl tetrazole-5-thiol. The thiol was dissolved in acetone, a solution of 30% sodium 2-ethylhexanoate in isopropanol was added, and the precipitate precipitated by filtration was the sodium salt of 1 sulfomethyl tetrazole-5-thiol.
The sodium salt of 7-amyloylaminocephalosporanic acid, 1-sulfomethyl tetrazole-5-thiol and sodium bicarbonate were dissolved in water, and th was heated at 70 °c. With ice bath cooling, with 3molll hydrochloric acid to pH 1.8. It was then extracted with ethyl acetate and filtered. The filtrate is subjected to column chromatography, and the developing solution is water containing methanol, and the content of methanol is continuously increased with the continuous development, and the cefonicid can be obtained. Cefonicid was dissolved in methanol and a 5% solution of sodium methoxide in methanol was added to pH = 7.0. Ethanol was then added to produce a precipitate. The precipitate was collected by filtration and dissolved in water to obtain the disodium salt of cefonicid after lyophilization.
Last Update：2022-01-01 08:52:28
Cefonicid - Use
Open Data Verified Data
The British GlaxoSmithKline company R & D, in 1984 to Monocid trade name in the United States, has been listed in Belgium, Spain, etc., for the treatment of sepsis, joint, skin, lower respiratory tract and urinary tract infections. Cefonicid sodium is a second-generation cephalosporin, which has antibacterial effect on most Gram-positive cocci, and has a wider antibacterial spectrum on Gram-negative bacilli than the first-generation cephalosporin, pneumonia Bacillus, Proteus mirabilis and so on have strong antibacterial effect. For urinary tract infections caused by sensitive bacteria, skin and soft tissue infections, respiratory infections, bone infections, gonorrhea.
Last Update：2022-01-01 08:52:29
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View History
Cefonicid
3'-Fluoro-2'-hydroxyacetophenone
盐酸多奈哌齐对照品
methyl 4-{2-[2-(1H-pyrrol-1-yl)benzoyl]carbohydrazonoyl}benzoate
N-甲基氨基甲酸混二甲苯酯
Carbamic acid, N-[8-(4-morpholinyl)octyl]-, (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl ester
4'-(4-羟基苯基)-2,2':6',2''-三联吡啶
Butanamide, 4-[(1,4-dihydro-5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-2-yl)thio]-N-(2-hydroxyethyl)-
(S)-3-羟基-1-辛炔
971-21-1
3'-Fluoro-2'-hydroxyacetophenone
盐酸多奈哌齐对照品
methyl 4-{2-[2-(1H-pyrrol-1-yl)benzoyl]carbohydrazonoyl}benzoate
N-甲基氨基甲酸混二甲苯酯
Carbamic acid, N-[8-(4-morpholinyl)octyl]-, (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl ester
4'-(4-羟基苯基)-2,2':6',2''-三联吡啶
Butanamide, 4-[(1,4-dihydro-5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-2-yl)thio]-N-(2-hydroxyethyl)-
(S)-3-羟基-1-辛炔
971-21-1