CS-2890
BAM15
CAS: 210302-17-3
Molecular Formula: C16H10F2N6O
CS-2890 - Names and Identifiers
| Name | BAM15 |
| Synonyms | BAM15 CS-2890 N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine [1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine, N5,N6-bis(2-fluorophenyl)- BAM 15 (N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) |
| CAS | 210302-17-3 |
CS-2890 - Physico-chemical Properties
| Molecular Formula | C16H10F2N6O |
| Molar Mass | 340.29 |
| Density | 1.548±0.06 g/cm3(Predicted) |
| Boling Point | 421.7±55.0 °C(Predicted) |
| Solubility | DMSO : 75 mg/mL (220.40 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| Appearance | powder |
| Color | white to beige |
| pKa | -2.40±0.50(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Use | BAM 15 is a mitochondrial proton uncoupling agent. BAM 15 is an oxidative phosphorylation (OXPHOS) uncoupling agent. |
| In vitro study | BAM 15 is able to increase O 2 consumption across a broad dosing range without increasing ROS. BAM 15 and FCCP are structurally unrelated and it is observed that low doses of BAM 15 from 100 nM to 1 μM increase cellular O 2 consumption rate (OCR) to a similar degree as FCCP, but higher concentrations from 1 μM to 50 μM reveal that BAM 15 is able to maintain uncoupled respiration at a high rate in a range of cell lines. BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin and does so across a broader concentration range than FCCP in both myoblasts and hepatocytes. BAM 15 induces mitochondrial swelling, demonstrating that BAM 15 is a protonophore. BAM15-treated cells are more viable than FCCP-treated cells when administered across a broad dosing range up to 50 μM. |
| In vivo study | Compare to vehicle-treated mice, animals that receive BAM 15 are protected from kidney injury as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less depletion of brush border villi, less obstruction of proximal tubules, and less immune cell infiltration. |
CS-2890 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.939 ml | 14.693 ml | 29.387 ml |
| 5 mM | 0.588 ml | 2.939 ml | 5.877 ml |
| 10 mM | 0.294 ml | 1.469 ml | 2.939 ml |
| 5 mM | 0.059 ml | 0.294 ml | 0.588 ml |
Last Update：2024-01-02 23:10:35
CS-2890 - Reference Information
| biological activity | BAM 15 is a novel uncoupling agent for the mitochondrial protonophore, it can protect mammals from acute renal ischemia-reperfusion injury and cold-induced microtubule injury. BAM 15 is also a potent activator of AMPK. BAM 15 reduces apoptosis caused by trafficking in iPS-differentiated retinal tissue. |
| Target | Value |
Last Update：2024-04-09 20:49:11
Supplier List
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: BAM15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BAM 15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: BAM15 Visit Supplier Webpage Request for quotationCAS: 210302-17-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
CS-2890
6-(BIOTINAMIDOCAPROYLAMIDO)CAPROIC ACID N-HYDROXYSU
hydrogen [3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-2-hydroxy-5-nitrobenzenesulphonato(3-)]hydroxychromate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
3-胺基-2-羟基-5-硝基苯磺酸
E3 ligase Ligand-Linker Conjugates 16
N4-(3-NITROPHENYL)-2,7-DINITRO-9-OXO-9H-4-FLUORENECARBOXAMIDE
5,6,7,8-四氢-[1,2,4]三唑并[4,3-A]吡嗪二盐酸盐
P-PHENYLGLYOXAL MONOHYDRATE
Aminomethylbenzoic Acid Impurity 1
4-(丙-2-基)-N-丙基苯-1-磺酰胺
6-(BIOTINAMIDOCAPROYLAMIDO)CAPROIC ACID N-HYDROXYSU
hydrogen [3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-2-hydroxy-5-nitrobenzenesulphonato(3-)]hydroxychromate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
3-胺基-2-羟基-5-硝基苯磺酸
E3 ligase Ligand-Linker Conjugates 16
N4-(3-NITROPHENYL)-2,7-DINITRO-9-OXO-9H-4-FLUORENECARBOXAMIDE
5,6,7,8-四氢-[1,2,4]三唑并[4,3-A]吡嗪二盐酸盐
P-PHENYLGLYOXAL MONOHYDRATE
Aminomethylbenzoic Acid Impurity 1
4-(丙-2-基)-N-丙基苯-1-磺酰胺